Annals of Clinical Neurophysiology

The Korean Society of Clinical Neurophysiology (대한임상신경생리학회)
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Upper Motor Neuron Involvement in Motor Neuron Disease: Motor Evoked Potentials Study

운동 신경원 질환에서의 상부 운동 신경원 침범: 운동 유발 전위 연구

  • Kim, Sung Hun (Department of Neurology and Physiology, College of Medicine, Seoul National University) ;
  • Park, Kyung-Seok (Department of Neurology, Seoul Paik Hospital) ;
  • Kim, Joo-Yong (Department of Neurology, College of Medicine, Kangwon National University) ;
  • Lee, Kwang-Woo (Department of Neurology and Physiology, College of Medicine, Seoul National University)
  • 김성훈 (서울대학교 의과대학 신경과학교실) ;
  • 박경석 (서울 백병원 신경과) ;
  • 김주용 (강원대학교 의과대학 신경과학교실) ;
  • 이광우 (서울대학교 의과대학 신경과학교실)
  • Published : 2000.11.30
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Abstract

Background & Objectives : Motor evoked potentials(MEPs) to magnetic trans cranial stimulation were performed to evaluate upper motor neuron involvement and relationship to lower motor neuron involvement in motor neuron disease patients. Method : MEPs were obtained in the 17 consecutive patients with motor neuron disease. These patients were divided into three group based on clinical evidence of upper and lower motor neuron involvement, bulbar symptom; amyotrophic lateral sclerosis(ALS), progressive muscular atrophy(PMA), progressive bulbar palsy(PBP). MEPs were recorded from abductor pollicis brevis and abductor hallucis muscles. Abnormal MEPs were defined by delayed central motor conduction time or absent MEP. Results : MEPs were abnormal in 64%(11/17) of patients; 100%(7/7) in ALS, 64%(4/7) in PMA, 0%(0/3) in PBP respectively. In 68 total recording muscles, 34 muscles had evidence of motor weakness and showed abnormal responses in 59%(20/34). Whereas 34 muscles with normal strength, only 3%(1/34) of muscles showed abnormal response. Conclusion : MEPs are well correlated with upper motor neuron signs in ALS and may detect masking upper motor neuron signs in PMA. The muscles with lower motor neuron sign(weakness) usually relate with abnormal MEPs reponses.

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