Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)
- Volume 33 Issue 6
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- Pages.541-545
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- 2000
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- 0374-8111(pISSN)
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- 2287-8815(eISSN)
The Effects of Alginic Acid on 3T3-L1 Cell's Differentiation
알긴산이 3T3-L1세포의 분화에 미치는 영향
- HWANG Hye-Jung (Faculty of Food Science and Biotechnology, Pukyung National University) ;
- PYEUN Jae-Hyeung (Faculty of Food Science and Biotechnology, Pukyung National University) ;
- NAM Teak-Jeong (Faculty of Food Science and Biotechnology, Pukyung National University)
- Published : 2000.11.01
Abstract
This study examines the effects of alginic acid, a source of dietary fiber, in a glucose-derived media. In particular, we examined how the presence or absence of alginic acid affected the differentiation and triglyceride densities of 3T3-L1 cells. We established that the addition of insulin-like growth factor-I (IGE-I) to 3T3-L1 cells results in acceleration of differentiation. We sought to determine the role of alginic acid in the production of fat by adding alginic acid to 3T3-L1 cells and examining its ability to limit or potentiate this stimulatory effects of IGE-I and IGF binding proteins. We have determined that alginic acid restricts 3T3-L1 cell differentiation and the creation of triglycerides, effectively attenuating 3T3-L1 cell metablolism and growth.
알긴산은 3T3-L1 세포의 분화를 억제하였다. 3T3-L1 세포의 분화를 촉진시키는 인자로 밝혀진 IGF-I과 insulin을 이용하여 알긴산의 분화에 미치는 영향을 검토한 결과, 알긴산은 insulin의 분화촉진작용을 특이적으로 억제하였다. 본 연구는 알긴산을 이용하여 알긴산의 지질 감소효과를 세포의 수준에서 검증하고자 하였다는 점에서 그 의의가 있으며, 이에 알긴산의 분화억제효과가 일어나는 메카니즘에 관한 연구가 있어야 할 것으로 생각된다.