Journal of Preventive Medicine and Public Health
- Volume 33 Issue 2
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- Pages.165-173
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- 2000
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- 1975-8375(pISSN)
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- 2233-4521(eISSN)
Assessment of the Glycophorin A Mutant Assay as a Biologic Marker for Low Dose Radiation Exposure
저선량 방사선 노출에 대한 생물학적 지표로서 Glycophorin A 변이발현율 측정의 유용성 평가
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Ha, Mi-Na
(Department of Preventive Medicine, Dankook University College of Medicine) ;
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Yoo, Keun-Young
(Department of Preventive Medicine, Seoul National University College of Medicine, Institute of Environmental Medicine, SNUMRC) ;
- Ha, Sung-Whan (Department of Therapeutic Radiology, Seoul National University College of Medicine) ;
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Kim, Dong-Hyun
(Department of Occupational Medicine, Dankook University Hospital) ;
- Cho, Soo-Hun (Department of Preventive Medicine, Seoul National University College of Medicine, Institute of Environmental Medicine, SNUMRC)
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하미나
(단국대학교 의과대학 예방의학교실) ;
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유근영
(서울대학교 의과대학 예방의학교실 및 의학연구원 환경의학연구소) ;
- 하성환 (서울대학교 의과대학 치료방사선과학교실) ;
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김동현
(단국대학교병원 산업의학과) ;
- 조수헌 (서울대학교 의과대학 예방의학교실 및 의학연구원 환경의학연구소)
- Published : 2000.06.01
Abstract
Objectives : To assess the availability of the glycophorin A (GPA) assay to detect the biological effect of ionizing radiation in workers exposed to low-doses of radiation. Methods : Information on confounding factors, such as age and cigarette smoking was obtained on 144 nuclear power plant workers and 32 hospital workers, by a self-administered questionnaire. Information on physical exposure levels was obtained from the registries of radiation exposure monitoring and control at each facility. The GPA mutant assay was performed using the BR6 method with modification by using a FACScan flow cytometer. Results : As confounders, age and cigarette smoking habits showed increasing trends with GPA variants, but these were of no statistical significance. Hospital workers showed a higher frequency of the GPA variant than nuclear power plant workers in terms of the NO variant. Significant dose-response relationships were obtained from in simple and multiple linear regression models. The slope of the regression equation for nuclear power plant workers was much smaller than that of hospital workers. These findings suggest that there may be apparent dose-rate effects. Conclusion : In population exposed to chronic low-dose radiation, the GPA assay has a potential to be used as an effective biologic marker for assessing the bone marrow cumulative exposure dose.
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