Blood Lead, Manganese, Aluminium and Silicon Concentrations in Korean Adults

한국인의 연, 망간, 알루미늄 및 실리콘의 혈중 농도

Objectives : This study was peformed to determine the reference values of blood lead, manganese, aluminium, and silicon in healthy adults. Methods : The subjects were 132 (67 male and 65 female), and classified to three age groups $(\leq39,\;40\sim49,\;and\;50\leq)$. Blood lead, manganese and aluminium were analyzed by atomic absorption spectrophotometer, and blood silicon was analyzed by direct current plasma optical emission spectrometer. Results : Blood lead levels(geometric mean, S.D) were (3.49, 1.70) ${\mu}g/dL$ in male and (3.04, 1.65) ${\mu}g/dL$ in female, but the difference is not significant, and there was no significant difference between age groups. Mean blood manganese level was $0.99{\pm}0.41{\mu}g/dL$, and there was no significant difference between sex or age groups. Mean blood aluminium level was $0.59{\pm}0.35{\mu}g/dL$, and there was no significant difference between sex or age groups. Mean blood silicon level was $54.41{\pm}27.64{\mu}g/dL$ in male and $43.34{\pm}23.51{\mu}g/dL$ in female, and the level in male was significantly higher than that in female (p<0.05). There was significant difference between age groups, and the oldest showed the highest level in male (p<0.05), but no significant difference between age groups in female. Conclusions : Authors hope that this study would provide basic data for determining reference values and evaluating health effects.

연, 망간, 알루미늄 및 실리콘에 대하여 직업적 노출이 없는 성인 132명(남성 67명, 여성 65명)을 대상으로 혈중 농도를 정량분석하여 다음과 같은 결과를 얻었다. 평균 혈중 연량(기하평근, 기하표준편차)은 남자군 (3.49, 1.70) ${\mu}g/dL$와 여자군 (3.04, 1.65) ${\mu}g/dL$로서 남자군에서 높았으나 유의한 차이는 없었고, 연령군별로는 남, 여 모두 차이가 없었다. 평균 혈중 망간량은 $0.99{\pm}0.41\;{\mu}g/dL$이었으며, 성별, 연령군별 유의한 차이는 관찰되지 않았다. 평균 혈중 알루미늄량은 $0.59{\pm}0.35\;{\mu}g/dL$이었으며, 성별, 연령군별 유의한 차이는 관찰되지 않았다. 평균 혈중 실리콘량은 남자군 $54.11{\pm}27.64\;{\mu}g/dL$, 여자군 $43.34{\pm}23.51\;{\mu}g/dL$로서 남자군에서 유의하게 높았고(p<0.05), 남자군의 경우 연령이 증가함에 따라 유의한 증가가 관찰되었으나(p<0.05), 여자군의 경우에는 연령군별로 차이가 없었다. 본 연구는 몇 가지 금속의 참고치 설정을 위한 기초 연구의 일환으로 앞으로의 연구에 자료로서 활용함으로써 이들 물질에 의한 인체장해의 평가와 예방관리에 일조 할 수 있을 것으로 생각된다.