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Luteal Prostaglandin F2α: New Concepts of Prostaglandin F2α Secretion and Its Actions within the Bovine Corpus Luteuma - Review -

  • Okuda, K. (Laboratory of Reproductive Endocrinology, Division of Animal Science and Technology Faculty of Agriculture, Okayama University) ;
  • Skarzynski, D.J. (Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Division of Reproductive Endocrinology and Pathophysiology)
  • Published : 2000.03.01

Abstract

The corpus luteum (CL) is a temporary endocrine gland whose main function is to secrete progesterone to support pregnancy. On the other hand, the cyclic bovine CL has also been shown to be a site of prostaglandin $F_{2{\alpha}}$ ($PGF_{2{\alpha}}$) production. Although there is general agreement that endometrial $PGF_{2{\alpha}}$ is an essential luteolysin in cattle, luteal $PGF_{2{\alpha}}$ seems to play a luteotropic role as an autocrine and/or paracrine factor, especially for the development and maintenance of the CL. This supposition is based on evidence that some of the prerequisites for autocrine/paracrine mechanisms are present, including local production of $PGF_{2{\alpha}}$ and the existence of specific binding sites within the CL. The purpose of this paper is to review the regulation of luteal $PGF_{2{\alpha}}$ secretion, its action on CL as an autocrine and/or paracrine factor and the receptivity of bovine CL to. $PGF_{2{\alpha}}$.

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Cited by

  1. Luteotropic Mechanisms in the Bovine Corpus Luteum: Role of Oxytocin, Prostaglandin F2 α, Progesterone and Noradrenaline vol.47, pp.3, 2001, https://doi.org/10.1262/jrd.47.125
  2. Regulation of luteal prostaglandin F production and its relevance to cell death: An in vitro study using rat dispersed luteal cells vol.83, pp.4, 2000, https://doi.org/10.1016/j.prostaglandins.2006.12.003