DOI QR코드

DOI QR Code

Hydrogenated Lecithin 과 Co-emulsifier를 사용한 Nano-some의 제조 메커니즘과 Kojic Acid 및 Kojic Dipalmitate의 캡슐화 방법

The Manufacturing Mechanism of Nano-some and Method of Capsulation of Kojic Acid and Kojic Dipalmitate with Hydrogenated Lecithin and Co-emulsifiers

  • 김인영 (제일제당(주) 피부과학연구소) ;
  • 제구환 (제일제당(주) 피부과학연구소) ;
  • 이주동 (제일제당(주) 피부과학연구소)
  • Kim, In-Young (Cheiljedang Corp., Cosmetic & Houshold Product R & D Center) ;
  • Jae, Koo-Hwan (Cheiljedang Corp., Cosmetic & Houshold Product R & D Center) ;
  • Lee, Joo-Dong (Cheiljedang Corp., Cosmetic & Houshold Product R & D Center)
  • 발행 : 2000.12.31

초록

We investigated the property of formation of mono-vesicle(designated nano-some) with using of the combined co-emulsifiers and phospholipid. Nano-some was prepared with hydrogenated lecithin(HL) and diethanolamine cetyl phosphate(DEA-CP) by swelling reaction. Kojic acid and kojic dipalmitate could be made stabilization by nano-some system using microfluidizer(MF). Nano-some has a good affinity to skin by means of this system. The composition was compounded by 2% of hydrogenated lecithin (phosphatidyl choline contained with 75%, 0.5% of DEA-CP and 0.5% of diglyceryl dioleate (DGDO). To make nano-some, several conditions of MF have to be considered as follows. The optimum pH was 6.0. The pressure was 10,000psi and passage temperature was at $306^{\circ}C$. The nano-some base was passed to homogenize continually 3 times through MF. The Particle size distributions of the vesicles were with in $57{\sim}75.7nm$(mean 66nm) by measuring the Zetasizer-3000. Zeta potential of vesicles with 3 times passage through MF was -24.8mV. Formations for nano-some vesicle certificated photograph by scanning electric magnification (SEM). Stability of nano-some was very good for 6months. The turbidity was very good transparency compared nano-some with liposome. It was formed the mono vesicle in the opposite direction to be formed the multi-lamellar vesicle of liposome.

키워드

피인용 문헌

  1. HL에 의한 프로비타민-$B_5$ 액정의 형성과 보습효과 vol.20, pp.2, 2003, https://doi.org/10.12925/jkocs.2003.20.2.4