Korean Journal of Radiology

  • 제1권3호
  • /
  • Pages.127-134
  • /
  • 2000
  • /
  • 1229-6929(pISSN)
  • /
  • 2005-8330(eISSN)
대한영상의학회 (The Korean Society of Radiology)
권호 표지

Airway Reactivity to Bronchoconstrictor and Bronchodilator: Assessment Using Thin-Section and Volumetric Three-Dimensional CT

  • Boo-Kyung Han (Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine) ;
  • Jung-Gi Im (Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine) ;
  • Hak Soo Kim (Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine) ;
  • Jin Mo Koo (Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine) ;
  • Hong Dae Kim (Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine) ;
  • Kyung Mo Yeon (Department of Radiology and the Institute of Radiation Medicine, Seoul National University College of Medicine)
  • 투고 : 2000.01.17
  • 심사 : 2000.08.01
  • 발행 : 2000.09.30
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초록

Objective: To determine the extent to which thin-section and volumetric three-dimensional CT can depict airway reactivity to bronchostimulator, and to assess the effect of different airway sizes on the degree of reactivity. Materials and Methods: In eight dogs, thin-section CT scans were obtained before and after the administration of methacholine and ventolin. Cross-sectional areas of bronchi at multiple levels, as shown by axial CT, proximal airway volume as revealed by three-dimensional imaging, and peak airway pressure were measured. The significance of airway change induced by methacholine and ventolin, expressed by percentage changes in cross-sectional area, proximal airway volume, and peak airway pressure was statistically evaluated, as was correlation between the degree of airway reactivity and the area of airways. Results: Cross-sectional areas of the bronchi decreased significantly after the administration of methacholine, and scans obtained after a delay of 5 minutes showed that normalization was insufficient. Ventolin induced a significant increase in cross-sectional areas and an increase in proximal airway volume, while the effect of methacholine on the latter was the opposite. Peak airway pressure increased after the administration of methacholine, and after a 5-minute delay its level was near that of the control state. Ventolin, however, induced no significant decrease. The degree of airway reactivity did not correlate with airway size. Conclusion: Thin-section and volumetric spiral CT with three-dimensional reconstruction can demonstrate airway reactivity to bronchostimulator. The degree of reactivity did not correlate with airway size.

키워드

과제정보

This study was partly supported by the Schering Grants, Korean Radiologic Society.

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