Maxillofacial Plastic and Reconstructive Surgery
- 제22권2호
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- Pages.155-163
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- 2000
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- 2288-8101(pISSN)
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- 2288-8586(eISSN)
난소 절제된 백서에서 에스트로젠 투여용량에 따른 대퇴골주 변화에 대한 연구
A Study on the trabecular change of Femur according to $17{\beta}-Estradiol$ Dosage in Ovariectomized Rat
- Kim, Seong-Joo (Department of Oral & Maxillofacial Surgery, College of Dentistry, Dankook University) ;
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Kim, Kyung-Wook
(Department of Oral & Maxillofacial Surgery, College of Dentistry, Dankook University) ;
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Lee, Jae-Hoon
(Department of Oral & Maxillofacial Surgery, College of Dentistry, Dankook University)
- 발행 : 2000.06.30
초록
Osteoporosis is the consequence of an imbalance between osteoclastic and osteoblastic activity, coupled with an increased rate of bone turnover observed with menopause. Estrogen is generally considered to maintain bone mass through suppression of bone resorption. The purpose of this study was to evaluate the rat femoral trabecular change not only in the deficiency of estrogen but also in the administration of estrogen following ovariectomy(OVX). 30 female Sprague-Dawley rats were subjected to bilateral OVX or sham surgery(control). Groups of OVX were divided into 4 groups. The first group was injected daily with vehicle alone for 20 days after 20 weeks following OVX. The additional groups of OVX was injected daily with low, medium, or high doses of
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