Enzymatic Synthesis of Methyl Fructoside Acrylate and Methacrylate

메틸프룩토시드 아크릴레이트와 메타크릴레이트의 효소적 합성

Methyl fructoside acrylate and methacrylate were synthesized by lipase-catalyzed glycosylation of acrylic acid, methacrylic acid and vinyl methacrylate with ${\beta}$-methyl fructoside in t-butanol as a reaction medium. From the optimum conditions of enzymatic synthesis for acrylate and methacrylate, we obtained 78% conversion for methyl fructoside acrylate and 93% conversion for methyl fructoside methacrylate. The polymerizable sugar acrylates have potential application as biomedical polymer such as hodrogel contact lens.

메틸프록토시드 아크릴레이트와 메타크릴레이트를 효소적 배당화법으로 합성한 결과, 아크릴산과 메타크릴산의 배당화 전화율은 각각 78%나 93%이었으며, 연성콘택트렌즈용 의용고분자를 제조하기 위한 생체 친화성 단량체로서 활용될 것으로 기대된다.