The Journal of the Korean Society for Microbiology (대한미생물학회지)

The Korea Society for Microbiology (대한미생물학회)
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Apoptosis Induction and Associated Factor of Staphylococcus aureus in J774A.1 Mouse Macrophage Cell Line

황색포도구균에 의한 J774A.1 마우스 대식세포주의 Apoptosis 유도 및 관련인자

  • Kim, Sang-Ho (The Institute of Medical Science, Department of Microbiology, Dong-A University College of Medicine) ;
  • Lee, Chang-Min (Department of Microbiology, Dong-A University College of Medicine) ;
  • Jeong, Soo-Jin (Department of Microbiology, Dong-A University College of Medicine) ;
  • Jeong, Min-Ho (Department of Microbiology, Dong-A University College of Medicine) ;
  • Kim, Jin-Koo (Department of Microbiology, Dong-A University College of Medicine) ;
  • Cha, Jae-Kwan (The Institute of Medical Science, Department of Microbiology, Dong-A University College of Medicine) ;
  • Lee, Hyung-Sik (The Institute of Medical Science, Department of Microbiology, Dong-A University College of Medicine) ;
  • Lim, Young-Jin (The Institute of Medical Science, Department of Microbiology, Dong-A University College of Medicine) ;
  • Lee, Sang-Hwa (Department of Microbiology, Dong-A University College of Medicine)
  • 김상호 (동아대학교 의과대학 미생물학교실, 의과학연구소) ;
  • 이창민 (동아대학교 의과대학 미생물학교실) ;
  • 정수진 (동아대학교 의과대학 미생물학교실) ;
  • 정민호 (동아대학교 의과대학 미생물학교실) ;
  • 김진구 (동아대학교 의과대학 미생물학교실) ;
  • 차재관 (동아대학교 의과대학 미생물학교실, 의과학연구소) ;
  • 이형식 (동아대학교 의과대학 미생물학교실, 의과학연구소) ;
  • 임영진 (동아대학교 의과대학 미생물학교실, 의과학연구소) ;
  • 이상화 (동아대학교 의과대학 미생물학교실)
  • Published : 2000.02.28
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Abstract

Staphylococcus aureus infections are often life-threatening. Relatively little is known about the host response to these infections, in particular, the implication of apoptosis induced by this microorganism. In this study, we have shown that S. aureus was cytotoxic to J774A.1 cell, a murine macrophage cell line. The cell death mediated by S. aureus occurred through apoptosis, as shown by increase in the proportion of fragmented host cell DNA. Although phagocytosis and NO production had important role in the induction of apoptosis, the contact between bacteria and host cells was not essential for this pathway. A certain bacterial product could also induce typical caspase-dependent apoptosis of J774A.1 cell. It is expected that new interpretation may be possible to host-parasite relationship based on these results.

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