대한미생물학회지 (The Journal of the Korean Society for Microbiology)

대한미생물학회 (The Korea Society for Microbiology)
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캔디다균 감염 마우스 모델에서 병독인자의 비교위험도

Relative Risk of Virulence Factors in Candida-Infected Mouse

  • 김동화 (연세대학교 원주의과대학 미생물학교실) ;
  • 신운섭 (관동대학교 의과대학 미생물학교실) ;
  • 이경호 (연세대학교 원주의과대학 미생물학교실) ;
  • 김경훈 (강원대학교 자연과학대학 생명과학부) ;
  • 박윤선 (관동대학교 의과대학 미생물학교실) ;
  • 박주영 (연세대학교 원주의과대학 미생물학교실) ;
  • 고춘명 (연세대학교 원주의과대학 미생물학교실)
  • Kim, Dong-Hwa (Department of Microbiology, Yonsei University Wonju College of Medicine) ;
  • Shin, Woon-Seob (Department of Microbiology, Kwandong University College of Medicine) ;
  • Lee, Kyoung-Ho (Department of Microbiology, Yonsei University Wonju College of Medicine) ;
  • Kim, Kyung-Hoon (Division of Life Sciences, College of Natural Sciencse, Kangwon National University) ;
  • Park, Yoon-Sun (Department of Microbiology, Kwandong University College of Medicine) ;
  • Park, Joo-Young (Department of Microbiology, Yonsei University Wonju College of Medicine) ;
  • Koh, Choon-Myung (Department of Microbiology, Yonsei University Wonju College of Medicine)
  • 발행 : 2000.08.31
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초록

Candida albicans is one of the most frequently isolated fungal pathogens in human. Recently, the prevalence of candida infection has markedly increased, partially due to the increase of immunocompromised hosts. Proposed virulence factors of the pathogenic Candida are the ability to form hyphae to adhere to epithelial cell surfaces, and to secrete acid proteinases and phospholipases. We measured the relative cell surface hydrophobicity (CSH) and the ability of proteinase production (PROT), phospholipase production (PLase), adherence to host epithelium (ADH), and hyphal transition (Germ). The relative risk of virulence factors was analyzed by lethality test in murine model of hematogeneously disseminated candidal infection. According to Cox's proportional hazard analysis, the statistically significant virulence factors were PROT, ADH, and CSH. PROT was the highest risk factor of them. To evaluate the applicability for the diagnosis and treatment of Candidiasis, we examined the protective effect of the active and passive immunizations with the materials purified from virulence factors and antibodies to them in Candia-infected mice model. The mean survival times of active and passive immunized groups were slightly longer than those of non-immunized groups.

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