한국전문물리치료학회지 (Physical Therapy Korea)
- 제7권3호
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- Pages.34-48
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- 2000
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- 1225-8962(pISSN)
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- 2287-982X(eISSN)
흰쥐의 탈신경근 위축에 미치는 운동의 효과
Exercise Effects on the Atrophy of Denervated Muscles in Rat
- Yoon, Bum-Chul (Dept. of Physical Therapy, College of Health Science, Korea University) ;
- Yu, Byong-Kyu (Dept. of Physical Therapy, Shin-gu College) ;
- Lee, Myoung-Hwa (Dept. of Physical Therapy, College of Health Science, Korea University)
- 발행 : 2000.09.17
초록
The purpose of this study was to determine the effects of mild-intensity exercise training on the denervated muscle atrophy in the sciatic nerve injured rat. Thirty-six male Sprague-Dawley rats (250~300 g) were randomly assigned into three groups; sham-denervated group (n=8), denervated group (n=8), and denervated-exercised group (n=20). Exercise consisted of treadmill running at 20 m/min speed with 0% grade for 30 min/day. The animals were decapitated at the second and sixth weeks postcrush. Soleus and medial gastrocnemius were immediately excised to be weighed. Type I and II fibers of the muscles were differentiated by m-ATPase (pH 9.4) stain, and fiber diameters were evaluated. The results were as follows: 1) The weight of the soleus and medial gastrocnemius muscles showed a tendency to increase in both the denervation-exercised groups compared to the denervated group. 2) In the 2-week denervation-exercised group, type II fiber diameter of soleus and type I fiber diameter of medial gastrocnemius were increased significantly compared to the denervated control group. 3) In the 6-week denervated-exercised group, type I fiber diameter of soleus and type II fiber diameter of medial gastrocnemius were hypertrophied significantly compared to sham-denervated group. The results of this study suggested that treadmill exercise partially prevented denervation atrophy in the soleus and medial gastrocnemius of the rat.