The Korean Journal of Nuclear Medicine (대한핵의학회지)
- Volume 34 Issue 4
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- Pages.294-302
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- 2000
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- 1225-6714(pISSN)
The Relationship between F-18-FDG Uptake, Hexokinase Activity and Glut-1 Expression in Various Human Cancer Cell Lines
다양한 사람 종양세포주에서 F-18-FDG의 섭취와 Hexokinase 활성 및 Glut-1 발현과의 상관관계
- Kim, Bo-Kwang (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
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Chung, June-Key
(Department of Nuclear Medicine, Seoul National University College of Medicine) ;
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Lee, Yong-Jin
(Department of Nuclear Medicine, Seoul National University College of Medicine) ;
- Choi, Yong-Woon (Department of Nuclear Medicine, Seoul National University College of Medicine) ;
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Jeong, Jae-Min
(Department of Nuclear Medicine, Seoul National University College of Medicine) ;
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Lee, Dong-Soo
(Department of Nuclear Medicine, Seoul National University College of Medicine) ;
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Lee, Myung-Chul
(Department of Nuclear Medicine, Seoul National University College of Medicine)
- 김보광 (서울대학교 의과대학 핵의학교실) ;
-
정준기
(서울대학교 의과대학 핵의학교실) ;
-
이용진
(서울대학교 의과대학 핵의학교실) ;
- 최용운 (서울대학교 의과대학 핵의학교실) ;
-
정재민
(서울대학교 의과대학 핵의학교실) ;
-
이동수
(서울대학교 의과대학 핵의학교실) ;
-
이명철
(서울대학교 의과대학 핵의학교실)
- Published : 2000.08.31
Abstract
Purpose: To investigate the mechanisms related to F-18-FDG uptake by tumors, F-18-FDG accumulation was compared with glucose transporter-1 (Glut-1) expression and hexokinase activity in various human cancer cell lines. Materials and Methods: Human colon cancer (SNU-C2A, SNU-C4, SNU-C5), hepatocellular carcinoma (SNU-387, SNU-423, SNU-449), lung cancer (NCI-H522, NCI-H358, NCI-H1299), uterine cervical cancer (HeLa, HeLa 229, HeLa S3) and brain tumor (A172, Hs 683) cell lines were used. After 24 hr incubation of
목적: 종양세포에서 F-18-FDG 섭취 기전을 규명하기 위하여 F-18-FDG 섭취와 포도당운반체-1 (Glut-1), hexokinase의 발현과의 상관관계를 조사하였다. 대상 및 방법: 사람의 대장암(SNU-C2A, SNU-C4, SNU-C5), 간암(SNU-387, SNU-423, SNU-449), 폐암(NCI-H522, NCI-H358, NCI-H1299), 자궁경부암(HeLa, HeLa 229, HeLa S3), 그리고 뇌암(A172, Hs 683)에서 기원한 암 세포주