대한한의학회지 (The Journal of Korean Medicine)

  • 제21권2호
  • /
  • Pages.79-86
  • /
  • 2000
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

몰약 전탕액이 배양 심근세포에 미치는 영향

Effects of Myrrha Water Extract on Rat Myocardial Cells in Cultures

  • 권강범 (원광대학교 한의과대학 생리학교실) ;
  • 조현익 (원광대학교 한의과대학 생리학교실) ;
  • 김구환 (원광대학교 한의과대학 생리학교실) ;
  • 김상범 (원광대학교 한의과대학 생리학교실) ;
  • 이호섭 (원광대학교 한의과대학 생리학교실) ;
  • 황우준 (원광대학교 한의과대학 침구학교실) ;
  • 박승택 (원광대학교 의과대학 해부학교실) ;
  • 류도곤 (원광대학교 한의과대학 생리학교실)
  • 발행 : 2000.06.01
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초록

Objectives and Methods : In order to elucidate toxic mechanism of myocardial damage and protective effect of myrrha water extract against cytotoxic effect of xanthine oxidase/hypoxanthine(XO/HX), cardioprotective effect of myrrha water extract was examined by MTT assay, LDH (Lactate Dehydrogenase) activity and heart beating rate after cultured myocardial cells derived from neonatal mouse were treated with various concentration of XO/HX, a free radical. Results : XO/HX induced a decrease of cell viability, an increase in the amount of LDH, and a decrease of heart beating rate on cultured myocardial cells in a dose-dependent manner. In cardioprotective effect of myrrha water extract, it showed a decrease in the amount of LDH and an increase of heart beating rate on cultured myocardial cells damaged by XO/HX. Conclusions : From the above results, it is suggested that XO/HX showed toxic effect in cultured myocardial cells derived from neonatal mouse and that myrrha water extract is very effective in the prevention of XO/HX-induced cardiotoxicity.

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