대한한의학회지 (The Journal of Korean Medicine)

  • 제21권2호
  • /
  • Pages.52-59
  • /
  • 2000
  • /
  • 1010-0695(pISSN)
  • /
  • 2288-3339(eISSN)
대한한의학회 (The Society of Korean Medicine)
권호 표지

방기 전탕액의 비만세포 매개성 아나필락시반응 및 종양괴사인자알파 생성 억제효과

Inhibitory Effect of Mast Cell-Mediated Anaphylactic Reactions and Tumor Necrosis $Factor-{\alpha}$ Production by Aqueous Extract of Sinomenium acutum stem

  • 김동혁 (원광대학교 한의과대학 신계내과학교실) ;
  • 송봉근 (원광대학교 한의과대학 신계내과학교실) ;
  • 이언정 (원광대학교 한의과대학 신계내과학교실) ;
  • 김형균 (원광대학교 한의과대학 신계내과학교실)
  • 발행 : 2000.06.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Objectives: The root and stem of Sinomenium acutum has been used for treatment of arthritis and neuralgia in oriental medicine. To find new substances of the anti-anaphylactic drugs, we studied Sinomenium acutum. Methods: To investigate the effect of this plant, the effect on anaphylactic reaction, plasma histamine level, and tumor necrosis $factor-{\alpha}-(TNF-{\alpha})$ production were measured after the aqueous extract of Sinomenium acutum stem (SSAE) was administrated to mice and rats. Results: The SSAE (0.1 to 1000 mg/kg) dose-dependently inhibited systemic anaphylactic reaction induced by compound 48/80 in mice. Especially, SSAE reduced compound 48/80-induced anaphylactic reaction with 50% at the dose of 1000 mg/kg. SSAE (100 to 1000 mg/kg) also significantly inhibited local anaphylactic reaction activated by anti-dinitrophenyl (DNP) IgE. When mice were pretreated with SSAE at a concentration ranging from 0.1 to 1000 mg/kg, the plasma histamine levels were reduced in a dose-dependent manner. SSAE (1 to 1000 g/ml) dose-dependently inhibited histamine release from the rat peritoneal mast cells (RPMCs) activated by compound 48/80 or anti-DNP IgE. The level of cAMP in RPMCs, when SSAE was added, increased compared with that of a normal control. In addition, SSAE (0.1 g/ml) had a significant inhibitory effect on anti-DNP IgE-induced $TNF-{\alpha}$ production. Conclusions: These results indicate that SSAE inhibits mast cell-mediated anaphylactic reactions and $TNF-{\alpha}$ production from mast cells.

키워드

참고문헌

  1. 常用中藥成分與藥理手冊 黃泰康
  2. Br J Phamacol. v.70 Some studies on the release of histamine from mast cells stimulated with polylysine Ennis M;Pearce, F.L.;Weston, P.M.
  3. Annu Rev Immunol. v.4 The receptor with high affinity for immunoglobulin E Metzger H;Alcaraz G;Hohman R;Kinet, J.P.;Pribluda V;Quarto R.
  4. 藥性歌括四百味白話解 北京中醫學院中藥方劑敎硏組
  5. Pharmaceutical Research and Development Screening methods for drug evaluation 3 Saito H;Nomura Y.;Suzuki L.;Tanaka H.;Yajima H.;Fukuda H.;Sezaki H.;Koga K.;Hirobe M.;Nakajime T.(Eds.)
  6. Nature v.339 Mast cell lines produce limphokines in response to cross-linkage of Fc RI or to calcium ionophores Plaut M;Pierce, J.H.;Watson, C.J.;Hanley-Hyde J;Nordon, R.P.;Paul, W.E.
  7. 대한한의학회지 v.18 no.1 즉시형 알레륵기 반응에 있어서 지실 물 추출액의 억제 작용기전 황광호;이언정;송봉근;김형균
  8. 대한한의학회지 v.18 no.2 침향의 항알레르기 효과에 대한 연구 김영학;이언정;송봉근;김형균
  9. 한방성인병학회지 v.3 no.1 황련해독탕가미방에 의한 면역글로불린(IgE)매개성 아나필락시의 억제 윤성찬;송봉근;이언정;김형균
  10. 대한한방내과학회지 v.19 no.2 유근피가 전신적 및 국소적 아나필락시에 미치는 효과 오명진;이언정;송봉근;김형균;김동혁;김성재
  11. 中藥大辭典 江蘇新醫學院
  12. 대한식물도감 이창복
  13. 本草求眞 黃宮銹
  14. The Pharmacology of Chinese Herbs Huang, K.C.
  15. Planta Med. v.65 no.1 Synergistic effects of the alkaloid sinomenine in combination with the immunosuppressive drugs tacrolimus and mycophenolic acid Vieregge, B.;Redch, K.;Kaever, V.
  16. Transplantation v.62 no.12 Immmunomdualtory effects of the alkaloid sinomenine in the high responder ACI-to-Lewis cardiac allogragt model Candinas, D.;Mark, W.;Kaever, V.;Miyatake, T.;Koyamada, N.;Hechenleitner, P.;Hancock, W.W.
  17. Int J Immunopharmacol. v.18 no.10 Amelioration of rat experimental arthritis by treatment with the alkaloid sinomenine Liu, L.;Buchner, E.;Beitze, D.;Schmidt-Weber, C.B.;Kaever, F.;Emmrich, F.;Kinne, R.W.
  18. J Amer Chem Soc. v.71 A family of long acting depressors Baltzly, R.;Buck, J.S.;De Beer, E.J.;Webb, F.S.
  19. J Immunol. v.139 125I-fibrin deposition in IgE-dependent immediate hypersensityivity reactions in mouse skin:demonstration of the role of mast cells using genetically mast cell-deficient mice locally reconstituted with cultured mast cells Wershil, B.K.;Mekori, Y.A.;Murakami, T.;Galli, S.J.
  20. Pharmacology v.39 Inhibitory effects of -adrenergic stimulants on increased vascular permeability caused by passive cutaneous anaphylaxis,allergic mediators and mediator releasers in rats Inagaki, N.;Miura, T.;Daikoku, M.;Nagai, H.;Koda, A.
  21. J Pharmacobiodyn. v.13 Effect of CV-3988, a specific antagonist against platelet activation factor, on homologous passive cutaneous anaphylaxis in the mouse ear Inagaki, N.;Miura, T.;Ohira, K.;Nagai, H.;Xu, Q.;Koda, A.
  22. Int Arch Allergy Immunol. v.82 Mechanism of action of an antiallergic agent, Amlexanox (AA-763), in inhibiting histamine release from mast cells Makino, H.;Saijo, T.;Ashida, Y.;Kuriki, H.H.;Maki, Y.
  23. Nature v.320 Cachectin and tumor necrosis factor as two sides of the same biologic coin Beuter, B.;Cerami, A.
  24. Proc Natl Acad Sci USA. v.88 Human dermal mast cells contain and release tumor necrosis factor a which induces endothelial leukocyte adhesion molecule I Walsh, L.J.;Trinichieri, G.;Waldorf, H.A.;Whitaker, D.;Murphy, G.F.
  25. J Exp Med. v.170 Interukin 3-dependent and independent mast cells stimulated with IgE and antigen express multiple cytokines Burd, P.R.;Rogers, H.W.;Gordon, J.R.;Martin, C.A.;Jayaraman, S.;Wilson, S.D.;Dvrorak, A.M.;Galli, S.J.;Dorf, M.E.