The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
권호 표지

The Immuno-Regulatory Effects of Onbi-tang and Dangguijakyak-san in Minimal Change Nephrotic Syndrome

미세변화 현증후군에서 온비탕과 당귀작약산이 면역조절기능에 미치는 영향

  • 안영민 (경희대학교 한의과대학 신계내과학교실) ;
  • 안세영 (경희대학교 한의과대학 신계내과학교실) ;
  • 두호경 (경희대학교 한의과대학 신계내과학교실)
  • Published : 2000.03.01
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this research is to investigate the synergistic effect of herb medicines with hydrocortisone and the regulation effect on the immune system of Onbitang and Dangguijakyaksan at the supernatant of PHA-P stimulated PBMC in the patients with minimal change nephrotic syndrome(MCNS). From the measurement of the concentration rate of IL-4, sCD23 and IL-13, the experiment yielded the following results : The Onbitang group showed a greater tendency to suppress IL-4 and IL-13 levels in MCNS group with no statistical significance. It showed very strong suppression in soluble CD23 compared with control group in MCNS group. The Dangguijakyaksan group, though not statistically significant, was inclined to suppress IL-4 level in MCNS group. It shows stronger suppression in sCD23 and IL-13 levels than these of control group in MCNS group. As for the synergistic effect, the group of hydrocortisone with herb medicines(Onbitang or Danguijakyaksan) produced more suppressive effect to IL-13 level in MCNS group than that of hydrocortisone-only group. They also tended to suppress sCD23 and IL-4 levels, though no statistical significance can be given. As to the suppressive effect of 1L-13 level, the group of Onbitang with hydrocortisone showed an increase of 22.6%, while the group of Dangguijakyaksan with hydrocortisone showed 14.7%. So Onbitang is more effective than Dangguijakyaksan. From the above results, a combinative treatment(herb medicines with hydrocortisone) can be an alternative method to substitute for steroid therapy. It can be a more effective therapy than steroid-only therapy because it is expected to reduce side effects and it shows more special effect to suppress IL-13 level. Based on the present results, further investigation concerning the serum IgE elevation is needed.

Keywords

References

  1. 慶熙大學校大學院 碩士學位論文 桂枝茯笭丸合오령산 및 비해분청음이 Puromycin Aminonucleoside로 誘發된 白鼠의 腎症에 미치는 影響 洪宗秀
  2. 仲景全書 금궤요약방론(卷下) no.?? 張仲景
  3. 臟象學 朴贊國
  4. 中國中西醫結合雜誌 v.13 164例腎炎患者血液流變學指標及其與血瘀證的關係 李國賢;언의;李晴;이빙방
  5. 東醫臨床內科學 II 安世永
  6. 和漢醫學雜誌 v.12 ぅシト抗CBM腎炎に對する溫脾湯の效果 服部智久;進藤省一郎;藤塚直樹;目比野智子;寺園芳樹;佐藤俊次;丸野政雄
  7. 東醫腎系學 杜鎬京
  8. Kidney Int v.13 A Report of the International Study of Kidney Disease in Children. Nephrotic syndrome in children;Prediction of histopathology from clinical and laboratory characteristics at the time of diagnosis
  9. 소아과학회지 v.36 미세변화신증후군의 예후 표지자에 관한 연구 조병수
  10. Lancet v.2 HLA atigens and atopic features in steroid-responsive nephrotic syndrome of childhood Thomson, P.D.;Barratt, T.M.;Stokes, C.R.;Turner, M.W.
  11. Am J Dis Child v.136 T-cell dysfnction in minimal change nephrotic syndrome of childhood Fodor, P.;Saitua, M.T.;Rodriqez, E.;Gonzalez, B.;Schlesinger, L.
  12. Pediatr Clin of North Am. v.89 no.4 Nephrotic syndrome in Childhood. Management and Treatment in Patients with Minimal Change Disease, Mesangial Proliferation, or Focal Glomerulosclerosis McEnery, P.T.;Strife, C.F.
  13. 소아과학회지 v.39 no.12 소아의 스테로이드 저항성신증후군의 임상병리학적 고찰 김정수;하일수;정해일;최용
  14. Kidney Int v.33 The longterm couse of cyclosporin-associated chronic nephropathy Myers, B.D.;Sibley, R.;Newtom, L.;Tomlanovich, S.J.;Boshkos, C.;Stinson, E.; Leutscher, Ja;Whitney, D.J.;Cplon, N.S.;Perlroth, M.G.
  15. 實用中醫腎病學 張大寧
  16. 慶熙韓醫大論文集 v.21 no.1 加減胃 湯령및 壯元湯이 Puromycin Aminonucleoside로 誘發된 白鼠의 腎症에 미치는 影響 金鍾大;安世永;杜鎬京
  17. 慶熙韓醫大論文集 v.19 no.1 六味地黃湯 및 四物湯이 Puromycin Aminonucleoside로 誘發된 白鼠의 腎症에미치는 組織學的 所見 安永敏;安世永;杜鎬京
  18. 경희의학 v.12 no.2 스테로이드의존성 빈회매발형 신증후군의 치료에 있어서 한방제제인 시령탕과 서양약물인 스테로이드의 병용효과에 대한 연구 두호경;조병수
  19. 千金翼方 孫思邈
  20. Lancet II v.II Pathologenesis of lipoid nephrosis: Adisorder of T-cell function Shalhoub, R.J.
  21. 景岳全書 v.??;?? 張介賓
  22. 精校 黃帝內經素問 洪元植(編)
  23. Nippon Jinzo Gakkai Shi v.38 no.11 Effect of Onpi-to on TGF-bata 1 in rats with 5/6 nephrectomized chronic renal failure Hattori, T.;Fujitsuka, N.;Kurogi, A.;Shindo, S.
  24. 서양의학자의 한방진료학 曺基湖;申吉祚(共譯)
  25. 現代東洋醫學 v.7 no.2 保險適用製劑 にょる 腎炎ネフロゼの漢方治療 菊谷豊彦
  26. Pediatr Nephrol v.3 The immunity in minimal change nephrotic syndrome Schnaper, H.W.
  27. J Am Soc Nephrol v.10 Th 1 and Th 2 cytokine mRNA profile in childhood nephrotic syndrome:Evidence for increased IL-13 mRNA Expression in Relapse Yap, H.K.;Cheung, W.;Murugasu, B.;Sim, S.K.;Seah, C.C.;Jordan, S.C.
  28. 대한면역학회지 v.12 B임파구의 CD23발현의 조절에 의한 새로운 Interleukin4 Bioassay 김수연;윤석란;이충은;정태화;변광호
  29. Clin Exp Immunol v.79 The inductive effect of IL-4 on IgG4 synthesis in human PBL Ishizaka, A.;Sakiyama, Y.;Nakanishi, M.;Tomizawa, K.;Osrik, E.;Kojima, K.;Taguchi, Y.
  30. J Exp Med. v.168 Mitogen pluse interleukin-4 induction of $C\varepsilon$ transscripts in B lymphocyte cells Rothman, P.;Lutzker, S.;Cook, W.;Coffman, R.;Alt, F.W.
  31. J Exp Med v.169 Induction of human IgE synthesis requires interleukin 4 and T/B cell interactions involving the T cell receptor/CD3 complex and MHC class II antigens Verceli, D.;Lutzker, S.;Cook, W.;Coffman, R.;Ali, F.W.
  32. J Am Soc Nephrol v.2 Elevation of interleukin-4 activities and mRNA expression in childhood minimal change nephrotic syndrome Cho, B.S.;Lee, C.E.;Pyun, K.H.
  33. Clin Exp Immunol v.100 Increased IL-2,IL-4 and interferon-gamma(IFN-$\gamma$ in steroid-sensitive nephrotic syndrome Neuhause, T.J.;Wadhwa, M.;Callard, R.;Barratt, T.M.
  34. 소아과학회지 v.40 no.12 신증후군에서 혈청 Cytokines에 관한 연구 장미영;이재호
  35. Jap J Nephrol v.33 Expression of $Fc{\varepsilon}R2$ in minimal change nephrotic syndrome Ogawa, S.;Dohi, K.;Yamada, H.;Hirayama, T.;Morita, H.;Iwano, M.;Ishikawa, H.
  36. J Exp Med v.179 Interleukin 13 is a B cell stimulating Factor Defrance, T.;Carayon, P.;Billian, G.;Guillemot, J.C.;Minty, A.;Caput, D.;Ferrara, P.
  37. J Immunol v.151 Effects of IL-13 on phennotype, cytokine production, and cytotoxic function of human monocyte De Waal Malefut, R.;Figdor, C.G.;Huijbens, R.;Mohan Peterson, S.;Bennett, B.;Culpepper, J.;Dang, W.;Zurawski, G.;De Vries J.E.
  38. Eur J Immunol v.25 Involvement of interleukin(IL)-13, but not IL-4, in spontaneous IgE and IgG4 production in nephrotic syndrome Kimata, H.;Fugimoto, M.;Furusho, K.
  39. Nephron Studies of glomerular permeability factor in patients with minimal change nephrotic syndrome Yoshizawa, N.;Kusumi, Y.;Matsmoto, K.;Oshima, S.;Takeuchi, A.;Kawamura, O.;Kubota, T.;Kondo, S.;Niwa, H.