Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
권호 표지

Three Months Subacute Toxicity of Water Soluble Dimethyl Dimethoxy Biphenylate Derivative in Rats

수용성 DDB 유도체의 3개월 반복투여독성에 관한 연구

  • 신민기 (서울대학교 수의과대학 독성학교실) ;
  • 손장원 (서울대학교 수의과대학 독성학교실) ;
  • 김민영 (서울대학교 수의과대학 독성학교실) ;
  • 방명주 (서울대학교 수의과대학 독성학교실) ;
  • 김정현 (서울대학교 수의과대학 독성학교실) ;
  • 최진혁 (서울대학교 수의과대학 독성학교실) ;
  • 김준성 (서울대학교 수의과대학 독성학교실) ;
  • 배미옥 (서울대학교 수의과대학 독성학교실) ;
  • 문전옥 (부산대학교 약학대학)
  • Published : 2000.06.01
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Abstract

The Three months subacute toxicity of water soluble dimethyl dimethoxy biphenylate derivative (DDB-S), newly formulated therapeutic agent for hepatitis, was invesgated in SD rats. The body weight and clinical signs were observed after intravenous injection of DDBs at doses of 57, 75 and 100 mg/kg/day for three months. Decrease in motor activity and tremor were observed above 75mg/kg treated groups. Statistically significant changes at serum biochemical analysis were found in some group, how-ever, those changes were within the normal range and had no relationship with dosage. There was no abnormal morphological and pathological findings in relation to DDB-S treatment. The no observable adverse effect level of DDB-S in rats was estimated to be 57 mg/kg/day in this study.

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