Preparation and Evaluation of Dry Alcohol Containing Red Ginseng Extract

홍삼 엑기스를 함유한 분말주의 제조 및 평가

To develop a dry alcohol containing red ginseng extract, dry alcohols composed of ethanol, water, dextrin and sodium lauryl sulfate were prepared using spray dryer, and their ethanol contents and encapsulation efficiencies were determined. An optimal dry alcohol containing red ginseng extract was chosen and the feeling for its oral administration was evaluated. Dextrin at dextrin/water weight ratios below 1.6/l and ethanol at ethanol/water weight ratios below 1/1 remarkably Increased both the ethanol contents and encapsulation efficiencies of dry alcohols. However dextrin at dextrin/water weight ratios above 1.6/1 and ethanol at ethanol/water weight ratios above 1/1 slightly decreased the both parameters. It might be due to the low solubility of dextrin in ethanol and limited diffusion coefficient of ethanol to the dextrin shell. furthermore, 0.5% (w/w) sodium lauryl sulfate gave the maximum ethanol content of dry alcohol. The more increased amounts of red ginseng extract were added, the more increased amounts of ginsenoside Rb1 but the more decreased amounts of ethanol were encapsulated in dry alcohols. A dry alcohol containing red ginseng extract was prepared with dextrin/ethanol/water (1/1/1, w/w/w) mixed solution, in which 0.5% (w/w) sodium lauryl sulfate and 20% (w/w) red ginseng extract were dissolved. It contained the ethanol contents of31.17$\pm$ 1.33% (w/w) and ginsenoside Rbl of 243.0$\pm$7.0 $\mu$g/g. It gave the moderate taste of red ginseng extract at Its oral administration with or without water Thus, the dry alcohol containing red ginseng extract can be further developed as a more convenient dosage form for red ginseng extract.

덱스트린/에탄올/물(1/1/l, w/w/w)의 혼합용액에 라우릴황산나트륨 0.5%(w/w) 및 홍삼 엑기스 20%(w/w)를 첨가한 조성을 가지고 분무건조하여 제조한 분말 홍삼주는 최대 에탄올(31.17$\pm$ 1.33%(w/w)) 및 ginsenoside Rbl(243.0$\pm$ 7.0$\mu\textrm{g}$/g)이 봉입된 미립구로서 용해 및 복용감이 우수한 새로운 홍삼 엑기스의 제형으로서의 가능성이 있다.