여성에서 절식이 체지방과 혈청의 Leptin 및 지질조성에 미치는 영향

Effect of Complete Fasting on Body Fatness, Serum Leptin and Lipid Profile in Women

  • 이은옥 (경희대학교 생활과학대학 식품영양학과) ;
  • 박현서 (경희대학교 생활과학대학 식품영양학과) ;
  • 신현대 (경희대학교 한방의료원 재활의학과)
  • 발행 : 2000.01.01

초록

The study was designed to observe the effect of complete listing for 10 days on body fatness, serum leptin level and lipid profile in thirty women who were admitted to fasting Clinical Program in Kyung-Hee Oriental Medical Center. Most of the subjects had food habits of over-eating and preferred oily foods which was correlated to the increase of body weight and BMI during realimentation. Average loss of body weight was 7.98kg and waist-hip ratio was significantly decreased during fasting. Body weight showed significant positive correlation with body fat(r=0.8182), lean body mass(r=0.7797) and total body water(r=0.7563). Body fat was gradually reduced after 9 days fasting, but lean body mass was not diminished any more after 7 days luring. Serum leptin level was significantly decreased after luring and re-feeding. The leptin showed significant positive correlation with body weight(r=0.9324), body mass index(r=0.8279) and body fat(r=0.8376). The levels of serum total cholesterol and LDL-C were significantly increased but HDL-C level was significantly decreased after fasting which increased could be harmful for persons with hypercholesterolemia. VLDL-C and triglyceride levels were not significantly decreased after fasting. Serum total free fatty acid level was significantly increased after fasting. These data suggest that the best way of maintaining the reduced body weight was to carry out the modification of food habits and behavior in daily lift. It could not be recommended to repeat often complete luting for reduction of body weight. (Korean J Nutrition 33(1) : 42-48, 2000)

키워드

참고문헌

  1. JAMA Medical News v.197 no.1 Diseased patients test starvation diet Dramatic teatment for obesity
  2. J Chronic Dis v.27 Relation of weight change to changes in atherogenic traits: the Framingham study Ashley FW;Kannel WB
  3. Atherosclerosis v.64 Early and late effects of weight loss on lipoprotein metabolism in sever obesity Rossner S;Bjotvell H
  4. Nutr Today v.31 no.4 Leptin: Product of the obese gene Behme MT
  5. J Nutr v.127 Leptin rapidly lowers food intake and elevates metabolic rates in lean and ob/ob mice Mistry AM;Swick AG;Romsos DR
  6. N Engl J Med v.334 Serum immunoreactive leptin concenturations in normal weight and obese humans Considirine RV;Sinha MK;Heiman ML;Kriauciunas A;Stephens TW;Nyce MR;Ohannesian JP;Marco CC;Mckee LJ;Bauer TL;Caro JF
  7. Am J Clin Path v.53 A colorimetric method for determination of total serum lipids based on the sulfo-phospho-vanillin reaction Frings;Christopher S;Dunn;Ralph T
  8. Clin Chem Acta v.22 A Colorimetric method for estimating serum triglycerides Fletcher MJ
  9. J Lab and Clin Med v.50 A Fluorometric method for total serum cholesterol McDougal DB;Farmer HS
  10. J Lipid Res v.11 Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions Burnstein M;Schlnoch HR;Morfin R
  11. Clin Chem v.18 Estimation of the concentration of low density lipoprotein cholesterol without use of the preparative ultracentrifuge Friedwald WT;Levy RI;Fredrickson DS
  12. J Lipid Res v.18 A more sensitive and stable colorimetric determination of free acids in blood Itaya K
  13. Effect of total starvation on body composition, plasma lipids and urinary excretion of minerals Kim BS
  14. Korean J Nutr v.23 no.5 Lee HK
  15. J Lab Clin Med v.102 Relationship of body fat distribution to blood pressure, carbohydrate tolerance and plasma lipids in health obese women Kalkboff RK;Hartz AH;Rupiey D;Kisseba AH;Kelber S
  16. Am J Clin Nutr v.4 Degree of masculine differentialtion of obesities: factor determining predisposition to diabetes, atherosclerosis, gout, and uric calculous disease Vague J
  17. Am J Caediol v.73 Waist circumference and abdominal sagittal diamerer: best simple anthropometric indexes abdominal visceral adipose tissues accumulation and related caediovascular risk in men and women Pouliot MC;Despres JP;Lemieux S(et al.)
  18. Biomed Pharmacother v.51 Regulation of ob gene and overexpression in obesity Guerre-Millo M
  19. Obese Res v.5 Relationship between circulation leptin and energy expenditure in adult men and women aged 18years to 81years Roberts SB;Nicholson M;Staten M;Dallal GE;Sawaya AL;Heyman MB;Fuss P;Greenberg AS
  20. Endocr J v.44 Human plasma leptin in obese subjects and diabetics Tasaka Y;Yanagisawa K;Iwamoto Y
  21. Neth J Med v.51 Insulin and leptin concentrations in obese humans during long term weight loss Toornvliet AC;Piji H;Westerndrop RG;Meinders AE
  22. Int J Obes Relat Metab Disord v.21 Leptin serum levels in normal weight and obese children and adolescents: relationship with age, sex, pubertal development, body mass index and insulin Falorri A;Bini V;Molinari D;Papi F;Celi F;Di SG;Berioli MG;Bacosi ML;Contessa G
  23. Atheriosclerosis v.21 Quantitative and qualitative serum lipoprotein analysis Calson LA;Ericsson M
  24. Arteriosclerosis v.4 Effect of weight loss in moderate obesity on plasma lipoprotein and apolipoprotein levels and on high density lipoprotein composition Zimmerman J Kaufmann NA;Fainaru M;Eisenberg S;Oshry Y;Friedlander Y;Stein Y
  25. Am J Clin Nutr v.33 Caloric restriction and / or mild exercise: effects on serum lipids and body composition Weltman A;Matter S;Stamford BA
  26. Am J Clin Nutr v.32 Unexpected decrease in plasma high density lipoprotein cholesterol with weight loss Thompson PD;Jaffery RW;Wing RR;Wood PD
  27. J Clin Invest v.11 Effect of weight reduction on plasma lipoprotein and adipose tissue metabolism in obese subjects Sorbris R;Pettersson BG;Nilson EP
  28. Arteriosclerosis v.3 Influence of weight reduction on plasma lipoprotein in obese patients Wolf RN;Grundy SM