Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Effects of Vitamin E on Antioxidative Defense System of Liver in Acute Cadmium-Poisoned Rats

식이 Vitamin E가 급성 카드뮴중독 흰쥐 간조직의 항산화계에 미치는 영향

  • Kim, Kwan-Ryu (Department of Food Engineering, Ansan Technical College) ;
  • Rhee, Soon-Jae (Department of Food Science and Nutrition, Catholic University of Taegu-Hyosung)
  • 김관유 (안산공업대학 식품영양학과) ;
  • 이순재 (대구효성가톨릭대학교 식품영양학과)
  • Published : 2000.01.01
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Abstract

The purpose of this study was to investigate the effects of vitamin E on antioxidative defense system of liver in acute cadmium poisoned rats. Sprague-Dawley male rats weighing 100$\pm$10gm were randomly assigned to one control and three cadmium injected groups. Cadmium injected groups were fed vitamin E free diet(OE-Cd group), 40mg vitamin E per kg diet(40E-Cd group) or 400 mg vitamin E per kg diet(400E-Cd group). Vitamin E level of normal group was 40mg per kg diet. Animals were injected intraperitoneally with 2.0mg Cd$^2$$\^$+//kg bw for 4 days after the rats were fed diets with three different levels of vitamin E for 2 and 4weeks. Activities of superoxide dismutase(SOD), glutathione peroxidase(GSHPx) and glutathione S-transferase(GST) were decreased in cadmium injected groups but those were significantly improved by dietary vitamin I supplementations. Vitamin E contents reduced glutathione(GSH) in the live were decreased in cadmium injected groups, but we., not significantly different among three groups with different levels of vitamin E supplementations. Contents of liver thiobarbituric acid reactive substance (TBARS) of 0E-Cd group were higher than those of 400E-Cd and 400E-Cd groups, but those were markedly alleviated according to vitamin E supplementations. These results indicate that cadmium poisoning in rats causes decreasing antioxidative defense system and increasing peroxidative damage in liver, however can be restored by vitamin E supplements. (Korean J Nutrition 33 (1) : 33-41, 2000)

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