Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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High Fat Diet or Exercise Training Alters Hepatic Total and Phospholipid fatty Acid Compositions in Rats

고지방식이 및 운동훈련이 흰쥐 간조직의 총지방산 및 인지질 지방산패턴에 미치는 영향

  • Jung, Chung-Eun (General Educaton, Kangnam University) ;
  • Um, Young-Sook (Research Institute of Food & Nutritional Sciences, Yonsei University) ;
  • Cha, Youn-Soo (Department of Food and Nutrition, Chonbuk National University) ;
  • Park, Tae-Sun (Department of Food and Nutrition, Yonsei University)
  • 정은정 (강남대학교 교양학부) ;
  • 엄영숙 (연세대학교 식품영양과학연구소) ;
  • 차연수 (전북대학교 식품영양학과) ;
  • 박태선 (연세대학교 식품영양학과)
  • Published : 2000.01.01
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Abstract

Effects of high fat diet and/or endurance exercise training on hepatic total and phospholipid(PL) fatty acid compositions were evaluated in rats fed one of the following diets for 31 days. control diet(CD, 5 wt% corn oil) or high fat diet(HFD, 35 wt% corn oil). Half of the rats in each group were exercise-trained regularly on a treadmill for 90 minutes/day during the entire feeding period. Total and PL fatty acid compositions of hepatic lipid extracts were determined by a gas-liquid chromatograph),. Endurance exercise training did not change the daily food intake, but significantly reduced body weight gain and feed efficiency ratio of rats, which were most prominent in animals fed HFD. Exercise training did not significantly change the percentages of ∑saturated fatty acids (SFA) and ∑polyunsaturated fatty acids(PUEA), but decreased the percentage of ∑monounsaturated fatty acids(MUFA) in hepatic total fatty acids, which might be associated with the decrease in (equation omitted) 9-desaturation index of hepatic total fatty acid metabolism. Exercise training significantly lowered the percentages of 16 : 0 and 22 : 5$\omega$3, and increased the percentages of 20 : 1 and 20 : 3$\omega$3 in both total and PL fatty acid compositions in rat liver. Both total fatty acid and PL fatty acid compositions of rat liver responded more sensitively to changes in dietary fat content than to endurance exercise training in this study. Feeding HFD, whoch contains high level of linoleic acid(LA, 18 : 2$\omega$6), significantly decreased the percentages of ∑SFA and $\Sigma$MUFA, and increased the percentages of ∑PUFA and ∑$\omega$6 fatty acids of hepatic total fatty acids. Hepatic total fatty acid composition was affected by dietary fat content and dietary fatty acid composition more sensitively than those found in hepatic PL fatty acid composition. HFD significantly decreased most of desaturation indices, while exercise training significantly decreased elongation index(20 : 5$\omega$3⇒22 : 5$\omega$3) of hepatic total and PL fatty acid metabolism in rats. (Korean J Nutrition 33(1) : 13-22, 2000)

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References

  1. J Sports Med Fitness v.31 Effects of swimming and land exercise versus swimming and water exercise on body composition of college students Kieres J;Plowman S
  2. Ann Rev Public Heath v.8 Physical activity and the incidence of coronary heart disease Powell KE;Thompson PD;Caspersen CJ;Kenrick JS
  3. Int J Sports Med v.10 Food intake and body composition in novice athletes during training period to run a marathon Jensen GMF;Grant CJJ;Satis WHH
  4. Korean J Nutr v.25 no.7 A study of effects of exercise on body composition of young adult male Moon SJ;Lee EK;Jeon HJ;Ko BK;Park SY;Kim HK;Kim BK
  5. Korean J Physical Education v.36 no.2 The effects of regular exercise on plasma lipoprotein metabolism Kim YS
  6. Korean J Nutr v.28 no.7 Improvement of liver function by weight control in children with fatty liver Park SH;Shin ES;Kim MH;Kim KM
  7. Am J Clin Nutr v.41 Dietary carbohydrates and endurance exercise Evans WJ;Hughes VA
  8. Understanding nutrition Whitney EN;Rofes SR
  9. Med Spot Sci v.11 Significance og skeletal muscle oxidative enzyme changes during endurance training and detraining Gollnick PD;More RL;Reedy M;Quintinskie JJ
  10. J Appl Physiol v.43 Fatty acid profile and cholesterol in skeletal muscle of trained and untrained men Thomas TR;Londeree BR;Gerhardt KO;Gehrke CW
  11. Am J Physiol v.274 Effects of Physical exercise on phospholipid fatty acid composition in skeletal muscle Andersson A;Sjodin A;Olsson R;Vessby B
  12. Am J Clin Nutr v.45 Effects of diet on plasma carnitine levels and urinary carnitine excretion in humans Cederblad MD
  13. Am J Phisiol v.263 Effects of fat availability on acetyl-CoA and acetylcarnitine metabolism in rat skeletal muscle Spriet LL;Dyck DJ;Cederblad G;Hultman E
  14. Biochim Biophys Acta v.1170 Effects of various n3/n6 fatty acid ratio contents of high fat diets on rat liver and heart peroxisomal and mitochodrial β-oxidation Vameq J;Vallee L;Lechene de la Porte P;Fontaine M;Craemer D;Branden C;Lafont H;Grataroli G;Nolbone G
  15. Nutr Today v.May/June ω3 fatty acid in growth and development and in heath and disease Simopoupos AP
  16. J Cell Physiol v.148 Dietary fish oils modify adipocytes structure and function Parrish CC;Pathy DA;Parkes JG;Angel A
  17. Lipids The effect of dietary fat level and quality on plasma lipoprotein lipids and plasma fatty acids in normocholesterolemic subjects Sander K;Johnson L;O'Dea K;Sinclair AJ
  18. J Nutr v.124 Dietary fat saturation and endurance exercise alter lipolytic sensitivity of adipocytes isolated from Yncatan miniature swine Meservey CM;Carey GB
  19. J Nutr v.105 Effect of exercise on tissue lipids and serum lipoproteins of rats fed two levels of fat Narayan KA;Mcmullen JJ;Butler DP;Wekerfield T;Calhoun WK
  20. J Nutr v.127 Consumption of high fat impairs reproductive performance in Spreque-Dawley rats Shaw MA;Rasmussen KM;Myers TR
  21. J BiolChem v.2 A simple method for the isolation and purification of total lipids from animal tissues Folch J;Lees M;Sloone-Stanley GH
  22. J lipid Res v.27 Direct transesterification of all classes of lipids in a one-step reaction Lepage G;Roy CC
  23. J Nutr v.123 Ago-related changes in rat adipose tissue cellurarity are altered by dietary restriction and exercise Bailey JW;Barker RL;Beauchene RE
  24. J Nutr v.117 Modulation of the exercise and retirement effects by dietary fat intake in hamsters Tsci AC;Gong TW
  25. J Kor Soc Food Sci Nutr v.27 no.6 changes of fatty acid compositions in hepatic total lipids and phospholipids of rats supplemented with cholesterol and taurine Park T;Oh JY;Kim IS;UM YS
  26. J Cell BioChem v.64 protective role of intraperitoneally administered vitamin E and selenium on the levels of total lipids, total cholesterol and fatty acid compositoin of muscle and liver tissues in rats Yilmaz O;Celik S;Cay M;Naziroglu M
  27. Am J Clin Nutr v.23 Comparison of effects of palmitic acid and stearic acid in the diet on serum cholesterol in man Grande F;Anderson JT;Keys A
  28. N Engl J Med v.318 Effect of dietary stearic acid on plasma cholesterol and lipoprotein levels Bonanome A;Grudy SM;
  29. Lipids v.31 Loss of arachidonic acid in rat liver after alcohol in halation Salem N;Reyzer M;Karanian J
  30. J Clin Invest v.97 Human fatty acid synthase is stimulated by a eucaloric low fat, high carbohydrate diet Hudgins LC;Hellerstein M;Seidman C;Neese R;Diakun J;Hirsch J
  31. J Am Coll Nutr v.17 no.6 Effects of dietary n-6 and n-3 lipids on antioxidant defense system in livers of exercised rats Venkatraman JT;Angkeow P;Sataigi N Femades G
  32. Am J Clin Nutr v.66 Changes in fat oxidation response to a high-fat diet Schrauwen P;Lichtenbelt EDM;Saris WHM;Westerterp KR
  33. BioChem Biophys Acta v.922 Cholesterol-induced microsomal changes modulate desaturase activities Leikin AI;Brenner RR
  34. Present Knowledge in Nutrition Ziegler EE;Filer LJ
  35. J Nutr v.124 Dietary fat, membrance phospholipids and obesity Pan DA;Hulbert AJ;Storlien LH
  36. Lipids v.7 The activating effect of dietary protein on linoleic acid desaturation Peluffo RO;de Gomez Dumm INT;Brenner RRB
  37. J Nutr v.101 Effect of protein and insulin on linoleic acid desaturation of normal and diabetic rats Peluffo RO;de Gomez Dumm INT;de Alaniz MMT;Brenner RRB
  38. Arch BioChem BioPhys v.16 Steroyl coenzyme-A desaturase activity in mouse liver microsomes of varying lipid compositions Holloway CT;Holloway PW
  39. Horm Metab Res v.22 no.8 Spontaneous diabetes in rat: evidence for insulin dependent liver microsomal delta 6 and delta 5 desaturase activities Mimouni A;Poisson JP