약학회지 (YAKHAK HOEJI)

  • 제44권1호
  • /
  • Pages.80-86
  • /
  • 2000
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

SKF 525A가 휜쥐의 대동맥에서 Sodium nitroprusside, Acetylcholine, Pinacidil에 의한 이완반응에 미치는 효과

The effect of SKF S25A on SNP-, Ach-, or Pinacidil-Induced Relaxation in the Aorta of Rat

  • 발행 : 2000.02.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

TEA, glibenclamide, L-NAME and SKF 525A-induced contraction were investigated using acetylcholine, sodium nitroprusside (SNP, NO donor) and pinacidil (ATP sensitive $K^{+}$ channel opener) in rat abdominal and thoracic aorta. The relaxant effects of acetylcholine, SNP and pinacidil were not different in the abdominal aorta and in the thoracic aorta. Acetylcholine-induced relaxation was dependent on endothelial cell, but pinacidil was independent endothelia cell. In the presence of TEA, glibenclamide, L-NAME, mepacrine and SKF 525A, acetylcholine and SNP did not change, but pinacidil-induced relaxation was significantly reduced in presence of glibenclamide, which is ATP sensitive $K^{+}$ channel blocker. SKF 525A, which is inhibitor of cytochrome P$_{450}$ dependent epoxygenase, partially inhibited the pinacidil-induced relaxation. These results indicate that the pinacidil-induced relaxation may be mediated by ATP sensitive $K^{+}$ channel and partially by EETs, which is produced by cytochrome P$_{450}$ dependent epoxygenase.enase.

키워드

참고문헌

  1. Am. J. Cardiol. v.77 Nitric oxide and nitrovasodilators:similarities,differences and interactions Ralph, A. K.
  2. Jpn. Heart. J. v.37 Nitric oxide in vascular remodeling Toshio, N.
  3. Blood Vessels v.27 Endothelium-derived Hyperpolarizing factor Kimihiro, K.
  4. Circ. Res. v.58 Cyclic guanosine monophosphate inhibition of contraction may be mediated through inhibition of phosphatidyl inositol hydrolysis in rat aorta Robert, M. R.
  5. Proc.Natl.Acad. Sci. v.85 Guanosine 5(-monophosphate modulates gating of high-conductance Ca²+ -activated K+ channels in vascular smooth muscle cells David, L. W.
  6. FASEB J. v.10 Cytochrome P₄, the arachidonic acid cascade and hypertension:New sistas for an old enzyme system Keiko, M.
  7. J. Biol. Chem. v.264 Regulation of intracellular Ca levels in cultured vascular smooth muscle cells Trudy, L. C.
  8. TiPS-July v.18 Endothelium-derived hyperpolarizing factor(s):updating the unknown Jean, V. M.
  9. J. Physiol. v.410 Some electical properties of the ecdothelium-dependent hyperpolarization recorded from rat arterial smooth muscle cells Guifa, D.
  10. J. Mol. Cell. Cardiol. v.27 Regulation of L-type calcium channels of vascular smooth muscle cells. Zhiling, X.
  11. Br. J. Pharmacol v.119 Endothelium-derived factors and hyperpolarization of the carotid artery of the guineapig Cathetine, C.
  12. Br.J. Pharmacol v.95 Acetylcholine releases endothelium derived hyperpolarization factor and EDRF from rat blood vessels Guifa, C.
  13. J. Pharmacol v.232 Selective blockade of endothelium dependent and glyceryl trinitrate-induced relaxation byhemoglobin and methylene blue in he rabbit aorta William, M.
  14. Br. J. Pharmacol. v.119 Mechanisms of L-N nitroginine/idomethcin-resistant relaxtion in bovine and porine coronary arteries. Wolfgng F, C.
  15. Br. J. Pharmacol. v.102 Difference in the K Katharine, B.
  16. Br. J. Pharmacol. v.113 Display of the characteristics of endothelium-derived hyperpolarizing factor by a cytochrome P₄-derived arachidonic acid matabolite n the cornary microcirculation Tohann, B.
  17. TiPS-May v.15 The pharmacology of intracellular Ca²+ -release channels Barbara, E. E.
  18. Circ. Res. v.78 Differental distribution of electrophysiologically distinct myocytes in conduit and resistance arteries determines their response to nitric oxide and hypoxia. Stephan, L. A.
  19. Br. J. Pharmacol. v.120 Characterization and modulation of EDHF-mediated relaxation in the rat isolated superior mesenteric arterial bed Andrey, I. M.
  20. Nature v.368 Nitric oxide directly activates calcium-dependent potassium channels in vascular smooth muscle Uictria, M. B.
  21. Am. Physiol. Society v.31 K channel opening mediates hyperpolarizations by nitric oxide donors and IJPs in opossum esophagus Francisco, S. C.
  22. Hypertension v.26 Relationship of arachidonic acid release to porcine coronary artery relaxation Neal, L. W.
  23. Br. J. Pharmacol v.107 Characterization of endothelium dependent relaxations resistant to nitro-L-arginine in the porcine coronary artery Tetsuhiko, N.
  24. Br. J. Pharmacol v.117 Endothelium-dependent relaxation and hyperpolarization evoked by bradykinin in canine coronary arteries:enhancement by exercisetraning Jean, V. M.
  25. Am. J. Physiol. v.270 Vasorelaxation by an endothelium-derived metabolite of arachidonicacid Sandra, L. P.
  26. Acta. Physiol. Scand. v.155 Regional differences in endothelium-dependent relaxation in the rat;contraction of nitric oxide and nitric oxide independent mechanisms Zygamut, P. M.
  27. Proc. Natl. Acad. Sci. v.91 Nitric oxide and cGMP cause vasorelaxation by activation of a charybdotoxin-sensitive K channel by cGMP-dependent protein kinase Stephan, L. A.
  28. Circ. Res. v.78 Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors William, B. C.
  29. J. Physiol. v.481.2 Characterization of endothelium-derived hyperpolarizing factos as a cytochrome P₄-derived arachidonic acid metabolite in mammals Markus, H.
  30. Br. J. Pharmacol. v.118 Effects of cytochrome P₄inhibitors on EDHF-mediated relaxation in the rat hepatic artery Peter, M. Z.