YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Omeprazole Based Antibiotic Regimens for Helicobacter pylori Infection in Peptic Ulcer Disease

Helicobacter pylori 감염 소화성궤양에서 Omeprazole중심 항생요법

  • 강현주 (숙명여자대학교, 임상약학대학원) ;
  • 강동훈 (가천의과대학, 길병원, 소화기내과) ;
  • 유종현 (가천의과대학, 길병원, 소화기내과) ;
  • 이숙향 (숙명여자대학교, 임상약학대학원)
  • Published : 2000.02.01
Download PDF
⟨ Previous Next ⟩

Abstract

Peptic ulcer is involved with Helicobacter pylori infection and antibiotic regimens are primary treatments. An optimal therapeutic regimen for eradication of Helicobacter pylori remains uncertain due to variable efficacy. The objectives of this study were to evaluate the efficacy of omeprazole based antibiotic regimens in bacterial eradication, healing of peptic ulcer and to identify factors affecting efficacy. Seventy-seven patients were enrolled in the prospective, open-trial from November 1997 to Setember 1998. H. pylori infection was identified with endoscopy, H. pylori stain and rapid urease test. The first group (OAC7) received omeprazole 20 mg twice daily for 4 weeks which were the same schedule for all, amoxicillin and clarithromycin 500 mg three times daily for 1 week; the second group (OAC14), for 2 weeks on the same regimen as the first; and the last group (OACD) has taken bismuth in addition to the OAC7 regimen for 1 week. Eradication of H. pylori and healing of peptic ulcer were evaluated with endoscopy and tests for H. pylori before and after treatments. There were no significant differences in eradication rates; 77% in OAC7, 76% in OAC14, 81% in OACD (p=0.935) and healing rates; 82% in OAC7, 71% in OAC14, 95% in OACD (p=0.179), respectively. Compliance had an relationship with eradication rates significantly among regimens (p=0.049). Twenty three cases (29%) complained of the minor side effects. In conclusion, OAC7 was better in convenience of dosing schedule and showed fewer side effects with shorter duration and lower cost while There were no significant differences in efficacy among regimens.

Keywords

References

  1. N. Engl. J. med. v.324 Helicobacter pylori and peptic ulcer disease Peterson, W. L.
  2. J. Antimicrob. Chemother v.29 Proposed mechanism for metronidazole resistance in Hecobecter pylori Cederbrant, G.;Kahlmeter. G.;Ljungh, A.
  3. Eur. J. Gastroentel. Hepatol. v.4 Evaluation of various multidrug eradication regimens for Helicobacter pylori Burette, A.;Glupzynski, Y.;Deprez, C.
  4. AM. J. Gastroentel. v.87 Meta-anaysis of the efficacy of antibiotic therapy in eradicating Helicobacter pylori Chiba, N.;Rao, B. V.;Radermaker, J. W.;Hunt, R. H.
  5. Aliment. Pharmacol. Ther. v.8 Treatments that impact favourrably upon the eradication of Helicobacter pylori and ulcer recurrence Tylgat, G. N. J.
  6. Aliment. Pharmacol. Ther. v.8 Helicobacter pylori eradication-under-standable caution but no excuse for inertia Penston, J. G.
  7. Gut v.41 Guidelines for clinical trials in Helicobacter pylori infection
  8. JAMA v.275 Medical treatment of peptic ulcer disease NIH
  9. Am. J. Med. v.100 Eradication of Helicobacter of pylori infection Hunt, R. H.
  10. Clin. Pharm. v.12 Helicobacter pylori and peptic ulcer disease Ateshali, A.;Lam, N. P.;Johnson, C. A.
  11. Gasrroenterlogy v.110 Relationship between Helicobacter pylori eradication and reduced duodenal and gastric ulcer recurrence:a review Hopkins, R. J.;Girardi, L. S.;Turney, E. A.
  12. Aliment Pharmacol Ther. v.11 For the ACT-10 study group. Short course therapy with amoxicillin-clarithromycin triple therapy for 10days(ACT-10)eradicates Helicobacter pylori and heals duodenal ulcer Wurzer, H.;Rodrigo, L.;Stamler, D.;Archambault, A.;Rokkas, T.;Skandalis, N.(et al.)
  13. Am J Gastroenterol v.93 Randomized clinical trial comparing two one week triple therapy regimens for the eradication of Helicobacter pylori in pateient infection and duodenal ulcer healing Forne, M.;Viver, M. J.;Esteve, M.;Banares-Ferandez, F.;Lite, J.;Espinos, J. C.(et al.)
  14. Aliment. Pharmacol. Ther. v.12 Ranitidine, bismuth citrate versus omeprazole triple therapy for the eradication of Helicobacter pylori and healing of duodenal ulcer Catalano, F.;Catanzaro, R.;Bentivegna, C.;Brogna, A.;Condorelli, G.;Cipolla, R.
  15. Aliment. Pharmacol. Ther. v.11 Helicobacter pylori eradication using a 7-day regimen of low dose clarithromycin, lansoprazole and amoxicillin Lim, A. G.;Walker, C.;Chambers, S.;Gould, S. R.
  16. Aliment Pharmacol. Ther. v.11 Stolte, M. Efficacy and tolerability of a one-week triple therapy consisting of pantoprazole, clarithromycin, and amoxicillin for cure of Helicobacter pylori infection in patients with duodenal ulcer Labenz, J.;Tillenburg, B.;Weismuller. J.;Lutke, A.