Archives of Pharmacal Research
- Volume 23 Issue 6
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- Pages.585-588
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Design and Synthesis of New DNA Photocleavers, 4'-Bromoacetophenone-Pyrrolecarboxamide Hybird Compounds
- Jeon, Ra-Ok (College of Pharmacy, Sookmyung Women's University) ;
- Paul A.Wender (Department of Chemistry, Stanford University)
- Published : 2000.12.01
Abstract
4-Bromoacetophenone-pyrrolecarboxarmide conjugates were designed and synthesized as photoinducible DNA cleaving agents which can generate monophenyl radicals capable of causing the hydrogen atom abstraction which initiates the scission of DNA.