Archives of Pharmacal Research
- 제23권4호
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- Pages.374-380
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Identification of Propentofylline Metabolites in Rats by Gas Chromatography/Mass Spectrometry
- Kwon, Oh-Seung (Toxicology Lab., Bioanalysis and Biotransfomation Research Center, Korea Institute of Science and Technology) ;
- Ryu, Jae-Chun (Toxicology Lab., Bioanalysis and Biotransfomation Research Center, Korea Institute of Science and Technology)
- 발행 : 2000.08.01
초록
Propentofylline (PPF, 3-methyl-1-(5-oxohexyl)-7-propylxanthine) has been reported to be a compound for treatment of both vascular dementia and dementia of the Alzheimer type. The short half-life (about 15 min) of PPF at the terminal elimination phase and poor bioavailability after oral administration of PPF to rabbits (Kim et al., 1992) suggest in part that this drug takes the extensive first-pass metabolism in the liver. In addition, the metabolic pathway for PPF remains unclear. The objective of this experiment is to identify urinary metabolites of PPF in rats. For the identification of the metabolites, rat urine was collected after oral administration of 100
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