Archives of Pharmacal Research
- 제23권4호
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- Pages.324-328
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
3D QSAR Studies on New Piperazine Derivatives with Antihistamine and Antibradykinin Effects
- Parkchoo, Hea-Young (School of Pharmacy, Ewha Womans University) ;
- Chung, Bum-Jun (School of Pharmacy, Ewha Womans University)
- 발행 : 2000.08.01
초록
Three dimensional QSAR studies for antihistamine and antibradykinin effects of new piperazine derivatives were conducted using the comparative molecular field analysis. Electrostatic and steric factors, but not hydrophobic factor, of the synthesized compounds were correlated with the antagonistic effect.