Archives of Pharmacal Research

  • 제23권3호
  • /
  • Pages.240-242
  • /
  • 2000
  • /
  • 0253-6269(pISSN)
  • /
  • 1976-3786(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

Immunomodulating Activity of a Polysaccharide Isolated from Mori Cortex Radicis

  • Kim, Hwan-Mook (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Han, Sang-Bae (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Lee, Ki-Hoon (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Lee, Chang-Woo (Korea Research Institute of Bioscience and Biotechnology(KRIBB)) ;
  • Kim, Chul-Young (College of Pharmacy, Seoul National University) ;
  • Lee, Eun-Ju (College of Pharmacy, Seoul National University) ;
  • Huh, Hoon (ollege of Pharmacy, Seoul National University)
  • 발행 : 2000.06.01
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초록

The immunomodulating activity of a polysaccharide isolated from Morus alba (PMA) root bark was examined in murine splenic lymphocytes. PMA enhanced proliferation of splenic lymphocytes in a synergistic manner in the presence of mitogens. However, PMA suppressed pri-may IgM antibody production from B cells, which was activated with lipopolysaccharide, a polyclonal activator, or immunized with a T-cell dependent antigen sheep red blood cells. Our observations showed that the immunomodulating activity of PMA increased lymphocyte proliferation and that PMA decreased antibody production from B cells, which was distinct from those of other plant-originated polysaccharides.

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