Archives of Pharmacal Research
- Volume 23 Issue 2
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- Pages.155-158
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- 2000
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- 0253-6269(pISSN)
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- 1976-3786(eISSN)
Cytotoxic Triterpenes from Crataegus pinnatifida
- Min, Byung-Sun (College of Pharmacy, Chungnam National University) ;
-
Kim, Young-Ho
(College of Pharmacy, Chungnam National University)
;
- Lee, Sang-Myung (College of Pharmacy, Chungnam National University) ;
- Jung, Hyun-Ju (College of Pharmacy, Chungnam National University) ;
- Lee, Jun-Sung (College of Pharmacy, Chungnam National University) ;
- Na, Min-Kyun (College of Pharmacy, Chungnam National University) ;
- :lee, Chong-Ock (Korea Research Institute of Chemical and Technology) ;
- Lee, Jong-Pil (Natural Medicinal Product Division, Korea Food and Drug Administration) ;
- Bae, Ki-Hwan (College of Pharmacy, Chungnam National University)
- Published : 2000.04.01
Abstract
Bioassay-guided fractionation of Crataegus pinnatifida (Rosaceae) gave two cytotoxic ursane-type triterpenes which were identified as uvaol (1) and ursolic acid (2) by physicochemical and spectroscopic methods. 3-Oxo-ursolic acid (3) was synthesized from ursolic acid (2) by Jones method. The cytotoxic activities of these compounds were tested against murine L1210 and human cancer cell lines (A549, SK-OV-3, SK-MEL-2, XF498, and HCT15) in vitro. Compounds 1 and 2 showed moderate cytotoxicities against L1210, whereas they showed weak activities against human cancer cell lines. However compound 3 exhibited potent cytotoxic activities both in murine and in human cancer cell lines.