Archives of Pharmacal Research
- 제23권2호
- /
- Pages.121-127
- /
- 2000
- /
- 0253-6269(pISSN)
- /
- 1976-3786(eISSN)
Synthesis and Cytotoxic Effects of Deoxy-tomentellin
- Han, Du-Seok (Department of Oral Anatomy, School of Dentistry) ;
- Jung, Kui-Ho (Department of Oral Anatomy, School of Dentistry) ;
- Jung, Woo-Jung (Department of Oral Anatomy, School of Dentistry) ;
- Oh, In-Kyo (Department of Environmental Industry, Wonkwang Health College) ;
- Kang, Kil-Ung (Department of Natural Products, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
-
Baek, Seung-Hwa
(Department of Natural Products, Professional Graduate School of Oriental Medicine, Wonkwang University)
- 발행 : 2000.04.01
초록
Cannabigerol (1, CBG), methyl 4-[(2E)-3,7-dimethyl-2,6-octad ienyl)oxy]-3-methoxybenzoate (2, DTM), 5-fluorouracil (3, FU) as a reference, and cannabidiol (4, CBD) were tested for their growth inhibitory effects against KB(ATCC NO, OCL 17) cell lines using two different assays, the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazoliumbromide (MTT) assay and the sulforhod-amine B protein (SRB) assay. These compounds showed inhibitory activity in vitro in the micromolar range against KB cell lines. In general, the antitumor activities of these compounds (1, 2, 3 and 4) were dose-dependent over the micromolar concentration range of 1 to 100 M. The comparison of
키워드