Parasites, Hosts and Diseases
- 제38권3호
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- Pages.151-158
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- 2000
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- 2982-5164(pISSN)
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- 1738-0006(eISSN)
Genetic heterogeneity of Pneumocystis carinii from rats of several regions and strains
- Chung, Byung-Suk (Department of Parasitology, Seoul National University College of Medicine) ;
- Pars, Yun-Kyu (Department of Parasitology Inha University College of Medicine) ;
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Huh, Sun
(Department of Parasitology College of Medicine Hallym University Chunchon) ;
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Yu, Jae-Ran
(Department of Parasitology College of Medicine Konkuk University) ;
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Kim, Jin
(Department of Parasitology College of Medicine Seonam University) ;
- Shi, Xiaohua (Department of Pharmacology Institute of Parasitic Disease, Chineses Academy of Preventive Medicine) ;
- Cho, Sang-Rock (Department of Cardiovascular Surgery, Kangnam General Hospital Public Corporation) ;
- Lee, Soon-Hyung (Department of Parasitology, Seoul National University College of Medicine) ;
- Hong, Sung-Tae (Department of Parasitology, Seoul National University College of Medicine)
- 발행 : 2000.09.01
초록
Pneumocystis carinii is a major opportunistic pathogen which has been found in the lungs of a wide variety of mammalian host species, and the fact suggests the possibility of intraspecific variation. Until now, P. carinii from different mammalian species are differentiated as subspecies, and the rats are known to be infected by two subspecies. The present study investigated genetic heterogeneity of P. carinii isolates from two strains of rats in Korea and China by molecular karyotyping, RFLP and sequencing analysis. Karyotypes of P. carinii were grouped into three, two from two strains of rats In Korea and one from rats in China. However RFLP of PCR product of ribosomal and MSG gene of the P. carinii isolates showed same pattern. The sequence homology rates of