Parasites, Hosts and Diseases
- Volume 38 Issue 2
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- Pages.103-106
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- 2000
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- 2982-5164(pISSN)
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- 1738-0006(eISSN)
Excretory-secretory product of Paragonimus westermani newly excysted metacercariae inhibits superoxide production of granulocytes stimulated with IgG
- Shin, Myeong-Heon (Department of Parasitology and Institute of Medical Science, College of Medicine, Ewha Womans University)
- Published : 2000.06.01
Abstract
It is well known that the cysteine proteases in excretory-secretory product (ESP) of Paragonimus westermani newly excysted metacercariae (PwNEM) are capable of degrading IgG in vitro. Recent evidence suggests that the IgG-coated surface, such as found on parasites, is one of the most effective physiologic stimuli for granulocyte activation. Therefore, this study was designed to investigate the effect of excretory-secretory product (ESP) of PwNEM on superoxide production of granulocytes stimulated with IgG The 96-well plates were coated with human IgG (0, 10, 30,
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