A Study on the Serotonin Metabolism and the Morphine-related Analgesic Mechanism in Mice Fed Tryptophan Supplemented Diet (I)

트립토판 보강식이를 섭취한 마우스에서 serotonin 대사와 orphine 진통기작 관련성에 대한 연구(I)

In this study we fed control diet and tryptophan supplemented diets containing 0.1,0.2,0.35% tryptophan to ICR mice for 1∼3 weeks to investigate the effects of tryptophan supplemented diet on pain sensitivity and the analgesic mechanism of serotonin. Animals fed tryptophan supplemented diets displayed increased antinociception when measured with hot plate and phenylquinone-writhing tests. And animals with typtophan supplemented diet had higher brain serotonin and 5-HIAA concentration than the control animals.