Effects Evodiae Fructus on the Blood Pressure in Spontaneously Hypertensive Rats

오수유가 선천성고혈압흰쥐의 혈압에 미치는 영향

  • 정수연 (식품의약품안전청 국립독성연구소 약리부) ;
  • 정수연 (식품의약품안전청 국립독성연구소 약리부) ;
  • 정수연 (식품의약품안전청 국립독성연구소 약리부) ;
  • 강주희 (식품의약품안전청 국립독성연구소 약리부) ;
  • 최기환 (식품의약품안전청 국립독성연구소 약리부) ;
  • 김주일 (식품의약품안전청 국립독성연구소 약리부)
  • Published : 2000.12.01

Abstract

The present study examined the effect of a methanol extract of Evodiae Fructus on the blood pressure in spontaneously hypertensive rats (SHR). The systolic blood pressure was measured after rats were pretreated with phentolamine, propranolol, or $N_{\omega}$-nitro-$_{L}$-arginine methyl ester(NAME) and subsequently received methanol extract of Evodiae Fructus. In SHR, intraperitoneal administration of methanol extract of Evodiae Fructus (0.5 mg/kg) produced antihypertensive effect that lasted for at least 4 hours. Antihypertensive effect of Evodiae Fructus was more stronger than that with $\alpha$-adrenergic receptor antagonist phentolamine and was not affected by $\beta$-adrenergic receptor antagonist propranolol. The antihypertensive effect of Evodiae Fructus was abolished by pretreatment of NAME. Our findings suggest Evodiae Fructus has an hypertensive effect, which may be mediated through nitric oxide synthesis.s.

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