Effects of Selective Thromboxane $A_2$-Receptor Antagonist, KT2-962 on Adriamycin-induced Nephrotoxicity in Rats

흰쥐에서 Adriamycin-유발 신독성에 대한 Thromboxane $A_2$ 수용체 길항제인 KT2-962의 효과

  • 문삼영 (한양대학교 의과대학교 약리학교실 의과학 연구소) ;
  • 이순복 (한양대학교 의과대학교 약리학교실 의과학 연구소) ;
  • 신현진 (한양대학교 의과대학교 약리학교실 의과학 연구소) ;
  • 고현철 (한양대학교 의과대학교 약리학교실 의과학 연구소) ;
  • 엄애선 (한양대학교 생활과학대학 식품영양학과) ;
  • 강주섭 (한양대학교 의과대학교 약리학교실 의과학 연구소)
  • Published : 2000.09.01

Abstract

The present study was designed to assess the protective effect of a selective thromboxane $A_2$ receptor antagonist, KT2-962 (KT2) and possible mechanisms of adriamycin(AD)-induced nephrotoxicity in rats. The male Wistar rats were given either of AD (7.5 mg/kg, i.v.) alone in the AD-group (n=5) or in KT2+AD- group (n=5) which is a combination of AD and KT2 (30 mg/kg/day, i.p.) for 10 days from 3 days before and 7 days after AD injection. The body weight, 24-hours urine volume, urine protein and urinary N-acetyl-$\beta$-D-glu-cosaminidase (NAG) activity were measured with an interval of 2 days during 1 week. BUN, serum creatinine and creatinine clearance were measured on the 7th day. KT2 has significantly suppressed AD-induced change of body weight, 24-hours urine volume, urine protein and urinary NAG activity in the KT2+AD-group. The change of BUN, serum creatinine and creatinine clearance were significantly inhibited in the B7T2+AD-group. Based on these results, it is concluded that KT2 prevents AD-induced nephrotoxicity and suggests that endogenous thromboxane A2 may play an important role in AD-induced nephrotoxicity in rats.

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