Antitumor Activity of the Intergeneric Protoplast Fusant between Lentinus edodes and Coriolus versicolor

표고와 운치의 원형질체 융합균주의 항암작용

  • 곽은경 (서울시립대학교 생명과학과) ;
  • 김하원 (서울시립대학교 생명과학과) ;
  • 심미자 (서울시립대학교 생명과학과) ;
  • 현진원 (서울대학교 의과대학 약리학교실) ;
  • 김병각 (서울대학교 약학대학 종합약학연구소)
  • Published : 2000.09.01

Abstract

Antitumor effect of LC43, a protein-bound ploysaccharide (M.W. 43 kDa) that was purified from intergeneric protoplast fusant of Lentinus edodes and Coriolus versicolor, was elucidated against mouse sarcoma 180 cell in vitro and in vivo. By injecting LC43 into ICR mice bearing solid or ascitic sarcoma 180, tumor regression and survival rates were investigated. To examine the effects of LC43 on immunopotentiation activity. immunoorgan weight, B cell differentiation, T cell activity and macrophage activation were determined. LC43 showed antitumor effects against both solid tumor and ascitic tumor of sarcoma 180. It did not change significantly the immunoorgan weight but potentiated immune responses such as B cell differentiation and the release of superoxide anion from macrophages. These results suggest that the protein-bound polysaccharide of LC43 exhibited antitumor activities through the activation of immune-related cells and acted as an immunmodulator.

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