General Pharmacology of Bamboo Salt

죽염의 일반약리작용

  • 유태무 (식품의약품안전청 국립독성연구소) ;
  • 김순선 (식품의약품안전청 국립독성연구소) ;
  • 노용남 (식품의약품안전청 국립독성연구소) ;
  • 이숙영 (식품의약품안전청 국립독성연구소) ;
  • 김옥희 (식품의약품안전청 국립독성연구소) ;
  • 류항묵 (식품의약품안전청 국립독성연구소) ;
  • 양지선 (식품의약품안전청 국립독성연구소)
  • Published : 2000.03.01

Abstract

This study has been carried out to investigate general pharmacological action of bamboo salt (jukyom) in terms of effects on central nervous system and cardiovascular system in experimental animals. After bamboo salt, crude salt or reagent-grade NaCl were orally administered into male ICR mice with dose of 2.0 g/kg, general behavioural syndromes such as body weight and locomotor activity, spontaneous motor activity, pento-barbital-induced sleeping time, muscle incoordination, electroshock-induced convulsion, body temperature and writhing response caused by 0.6% acetic acid solution were observed. Bamboo salt had no influences in these indices for examinition of effect on central nervous system. Additionally, conscious male Sprague Dawley rats fastened overnight won ere treated with bamboo salt, crude salt or reagent-grade NaCl (2.0 g/kg, p.o.) to examine the effect of these salts cardiovascular system. Systolic, median and diastolic food pressure and heart rate were dertemined using tail cuff indirect method. Treatment with Hydralazine (50 mg/kg, p.o) as a positive control produced the decreases in systolic, median and diastolic blood treasure and an increase in heart rate. whereas no changes were observed in bamboo salt, crude salt and reagent-grade NaCl treated groups. These results strongly suggest that bamboo salt may have no effects on general pharmacology of central nervous systems and cardio-vascular systems.

Keywords