Biomolecules & Therapeutics
- 제8권1호
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- Pages.27-31
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- 2000
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- 1976-9148(pISSN)
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- 2005-4483(eISSN)
SHR(Spontaneously Hypertensive Rat)를 이용한 송엽, 익모초 추출물의 항고협알 작용
Anti-hypertensive Effects of Pini Folium and Leonuri Herba Extract on Spontaneously Hypertensive Rat (SHR)
초록
The aim of this study was to investigate a potential effect of treatment of spontaneously hypertensive rats (SHR) with Pini Folium or Leonuri Herba extracts. Male SHR were treated with extracts for 2 or 4 weeks starting at 13 weeks of age. We found that oral treatment with the methanol extract from Pini Folium or Leonuri Herba (1g/Kg/day) significantly decreased mean blood pressure to 85.4% and 78.6% respectively in compare with untreated control SHR. Treatment with the extract from Pini Folium for 4 weeks during hypertension development phase (starting 9 weeks of age) resulted in a partial prevention of hypertension development. There were no significant differences for body weight between untreated and Pini Folium treated SHR.