Journal of Veterinary Clinics (한국임상수의학회지)

The Korean Society of Veterinary Clinics (한국임상수의학회)
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Clinicopathological Diagnosis of Gentamicin and Ethylene glycol Induced Acute Renal Failure in Dogs

개에서 Gentamicin과 Ethylene glycol에 임상병리학적 진단

  • 김지현 (제주대학교 농과대학 수의학과) ;
  • 이영재 (제주대학교 농과대학 수의학과) ;
  • 이경갑 (제주대학교 농과대학 수의학과)
  • Published : 2000.12.01
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Abstract

The diagnostic method was, evaluated in experimentally induced acute renal failure in doges. Ten male dogs weighing from 5 to 10 kg were assigned to two groups(gentamicin & ethylene glycol treated group) al random. Gentamicin sulfate at 10 mg/kg of body weight, t.i.d., for 7 days and ethylene glycol at 3 ml/kg of body weight once used in a randomized complete block design with tee treatments in block. The samples(blood, urine) were collected before and 1,3,5,7,9 and l1th day after administration. The serum creatinine concentration and BUN(blood urea nitrogen) were sig- nificantly increased at the 7th day than before administration in gentamicin treated group (p<0.05), bolt there was significant increase at the 1st day than before administration in ethylene glycol treated group(p<0.05). The urine GGT(gramma glutamyl transpeptidase) and GGT/creatinine were significantly increased at the 1st (lay after administration in gentamicin treated group (p<0.05). But in ethylene glycol treated group, there was no significant changes. The value of FENa (fractional excretion of sodium) was significantly increased at the 3rd day after administration in gentamicin treated group and the 1 st day after administration in ethylene glycol treated group (p<0.05). These results suggest that FENa was a good parameter of renal function in dogs with acute renal failure.

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References

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