Lipopolysaccharide Synergizes with Interferon-${\gamma}$ to Induce Expression of Mig mRNA in Mouse Peritoneal Macrophages

  • Kim, Young-Ho (Department of Microbiology, College of Medicine, Yeongnam University) ;
  • Kim, Hee-Sun (Department of Microbiology, College of Medicine, Yeongnam University)
  • Published : 2000.10.01

Abstract

Lipopolysaccharide (LPS) is responsible for the tissue injury that occurs following the invasion of multicelluar organisms by Gram-negative microbes. The effect of LPS on IFN-$\gamma$-induced chemokine Mig gene expression in mouse peritoneal macrophages was investigated. Very little Mig mRNA was detectable upon exposure to LPS without IFN-$\gamma$. Although LPS alone is only minimally effective, LPS plus IFN-$\gamma$ synergized to produce a high level of Mig mRNA in the peritoneal macrophages. This synergy was not dependent on a new protein synthesis, and was not controlled at the level of the gene transcription. Futhermore, LPS did not increase IFN-$\gamma$-induced Mig mRNA stability. Accordingly, it is suggested the LPS may synergize the expression of IFN-$\gamma$-induced Mig mRNA through a process that depends on a pretranscriptional level or concurrent Mig mRNA translation.

Keywords

References

  1. Phagocytic Cells Adams. D. O.;T. A. Hamilton
  2. J. Biol. Chem v.271 Differential regulation of the stability of cytokine mRNAs in lipopolysaccharide-activated blood monocytes in response to interleukin-10 Brown, C. Y.;C. A. Lagnado;M. A. Vadas;G. J. Goodall
  3. Biochemistry v.18 Isolation of biologically active RNA from sources enriched in ribonuclease Chirgwin, J. M.;R. J. Pryzbyla;R. J. Macdonald;W. J. Rutter
  4. Int. J. Exp. Pathol v.75 Interferon-γ and polyunsaturated fatty acids increase the binding of lipopolysaccharide to macrophages Darmani, H. J.;J. Parton;L. L. Harwood;S. K. Jackson
  5. Science v.264 Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins Darnell, J. E.;I. M. Kerr;G. R. Stark
  6. J. Immunol v.149 Evidence for IFN-gamma as a mediator of the lethality of endotoxin and tumor necrosis factor-alpha Doberty, G. M.;J. R. Lange;H. N. Langstein;H. R. Allexander;C. M. Muresh;J. A. Norton
  7. J. Leukocyte Biol v.61 Mig and IP-10:CXC chemokines that target lymphocytes Farber, J. M.
  8. J. Immunol v.142 IFN-γ and IFN-β independently stimulate the expression of lipopolysacchride-inducible genes in murine peritoneal macrophages Hamilton, T. A.;N. Bredon;Y. Ohmori;C. S. Tannenbaum
  9. Infect. Immun v.67 Gamma interferon augments macrophage activation by lipopolysaccharide by two distint mechanisms,at the signal trans duction level and via an autocrine meshanism involving tumor necrosis factor alpha and interleukin-1 Held, T. K.;W. Xiao;Y. Liang;V. K. Dhananjaya;S. C. Alan
  10. J. Exp. Med. v.171 interferon gamma, a mediator of lethal lipopolysaccharide-induced Shwartzman-like shock reactions in mice Hermans, H.;J. Van Damme;C. Dillen;R. Dijkmans;A. Billau
  11. J. Biol. Chem. v.273 Hyaluronan fragments synergize with interferon-γ to induce protein C-X-C chemokines Mig and interferon-inducible protein-10 in mouse macrophages Horton, M. R.;M. M. Charlotte;B. Clare;L. Fang;M. F. Joshua;H. D. Jennifer;P. Ellen;L. O. Bonnie;M. W. timothy
  12. J. Immunol v.152 Regulation of neutrophil-derived chemokine expression by IL-10 Kasama, T.;R. M. Strieter;N. W. Jukacs;M. D. Bufdick;S. L. Kunkel
  13. J. Leukocyte. Biol v.64 IL-10 suppresses LPS-induced KC mRNA expression via a traslation-dependent decrease in mRNA stability Kim, H. S.;D. Amstrong;T. A. Hamilton;J. M. Tebo
  14. Cell. Immunol v.109 Regulation of tumor necrosis factor (TNF) expression:Interferon-γ enhances the accumulation of mRNA for TNF induced by lipopolysaccharide in murine peritoneal macrophages Koerner, T. J.;D. O. Adams;T. A. Hamilton
  15. Biochem. Biophys. Res. commun v.144 The early competence genes JE and KC are differentially regulated in murine peritoneal macrophages in response to lipopolysaccharide Koerner, T. J.;T. A. Hamilton;M. Introna;C. S. Tannenbaum;R. C. Bast;D. O. Adams
  16. J. Immunol v.163 Regulation of macrophage chemokine expression by lipopolysaccharide in vitro and in vivo Kopydlowski, K. M.;A. S. Cindy;M. J. Cody;N. V. Rooijen;M. Jennifer;T. A. Hamilton;S. N. Vogel
  17. J. Microbiol. Biotechnol v.9 Newly synthesized phospodiesterase 4(PDE4) inhibitor, DEP205505; Inhibitor of TNF-α secretion and mRNA expression LEE, S. K.;S. A. Lee;H. B. Byun;M. L. Cho;W. U. Kim;S. H. Park;C. S. Cho;Y. S. Joo;S. S. Lee;E. S. Yoo;H. J. Son;H. Y. Kim
  18. J. Nicrobiol. Biotechnol v.10 IL-6 mRNA expression in mouse peritioneal macrophages and NIH 3T3 fibroblasts in response to Candida albicans Lee, Y. S.;H. S. Kim;S. K. Kim;S. D. Kim
  19. J. Immunol v.106 Regulation of hyaluronan-induced chemokine gene expression by IL-10 and IFN-γ in mouse macrophages Maureen, R. H.;D. B. Marie;M. S. Robert;B. clare;W. N. Paul
  20. Immunobiology v.187 Nuclear factor kappa B, a mediator of lipopolysaccharide effects Muller, J. M.;H. W. Ziegler-Heitbrock;P. A. Baeuerie
  21. Biochem. Biophy. Res. Commun v.198 Cell type and stimulus specific regulation od chemokine gene expression Ohmori, Y.;T. A. Hamilton
  22. J. Immunol v.153 IFN-γ selectively inhibits lipopolysaccharide-inducible JE/monocyte chemoattactant protein-1 and KC/GRO/melanoma growth-stimulating activity gene expression in mouse peritoneal macrophages Ohmori, Y.;T. A. Hamilton
  23. J. Biol. Chem v.268 Cooperative interaction between interferon (IFN) stimulus response element and kB sequence motifs controls IFN-γ and lipopolysacchride-stimulated trascription from the murine IP-10 promoter Ohmori, Y.;T. A. Hamilton
  24. J. Immunol v.148 $Ca^2+$ and calmoduline selectively regulate lipopolysacchride-inducible cytokine mRNA expression in murine peritoneal macrophages Ohmori, Y.;T. A. Hamilton
  25. J. Cell. Physiol v.148 Modulation of $Na^+$/$K^+$ exchange potentiates lipopolysaccharide-induced gene expression in murine peritoneal macrophages Ohmori, Y.;E. Reynolds;T. A. Hamilton
  26. J. Biol. Chem v.272 Synergy between interferon- and tumor necrosis factor-α in transcriptional activation by cooperation between signal transducer and activator of trascription 1 and nuclear factor kB Dhmori, Y.;R. D. Schreiber;T. A. Hamilton
  27. J. Immunol v.155 Two structurally distint kB sequence motifs cooperative control LPS-induced KC gene transcription in mouse macrophages Ohmori, Y.;S. Fukumoto;T. A. Hamilton
  28. J. Microbiol. Biotechnol v.9 Comparison of nitric oxide, hydrogen peroxide, and cytokine production in RAW 264.7 cells by Bifidobacterium and other intestinal bacteria Om, A. S.;S. Y. Park;I. K. Hwang;G. E. Ji
  29. Mol. Med. v.4 induction of the chemokine b peptide, MIP-1α and MIP-1β, by lipopolysaccharide is differentially regulated by immunomodulatory cytokines γ-IFN, IL-10, IL-4, and TGF-β Sherry, B.;M. Espinoza,K. R. Manogue;A. Cerami
  30. J. Immunol v.162 Gene expression and production of the monokine induced by IFN-γ(MIG), IFN-inducible T cell a chemoattractant (I-TAC), and IFN-γ-inducible protein-10 (IP-10)chemokines by human neutrophils Sara, G.;M. Martina;C. Federica;L. Carlo;V. Lucia;O. Henrik;M. Marianne;L. Fang;F. Joshua;A. C. Marco
  31. Blood v.89 Mig, the monokine induced by interferon-γ, promotes tumor necrosis in vivo Sgadari, C.;J. M. Farber;A. L. Angiloillo;F. Liao;J. Teruya-Feldstein;P. R. Burd;L. Yao;F. Gupta;C. Kanegane;G. Tosato
  32. J. Immunol v.151 IFN-gamma and lipopolysaccharide differentially modulate expression of tumor necrosis factor receptor mRNA in murine peritoneal macrophages Tannenbaum, C. S.;J. A. Major;T. A. Hamilton
  33. J. Immunol v.162 The CXC shemokines IP-10 and Mig are necessary for IL-12-medicated regression of the mouse RENCA tumor Tannenbaum, C. S.;R. Tubbs;D. Armstrong;J. H. Finke;R. M. Bukowski;T. A. Hamilton
  34. J. Immunol v.104 Chracterization of lipopolysaccharide-induced macrophage gene expression Tannenbaum, C. S.;T. J. Korner;M. M. Jansen;T. A. Hamilton
  35. J. Immunol v.105 Genomis cloning and promoter analysis of macrophage inflammatory protein (MIP)-2, MIP-1α, and MIP-1b, members of the chemokine superfamily of proinflammatory cytokines Winmer, T.;K. R. Mangue;A. Cerami;B. Sherry
  36. Mol.Cell.Biol v.14 A unique palindromic element mediates gamma interferon induction of mig gene expression Wong, P.;C. W.;Severns;N. B. Guyer;T. M. Wright