한국잠사곤충학회지 (Journal of Sericultural and Entomological Science)

한국잠사학회 (Korean Society of Sericultural Science)
권호 표지

뇌조직의 활성산소 및 그 제거효소에 미치는 누에분말의 영향

Effect of Silkworm Powder on Oxygen radicals and Their Scavenger Enzymes in Brain membranes of SD Rats

  • 최진호 (부경대학교 식품생명공학부) ;
  • 김대익 (부경대학교 식품생명공학부) ;
  • 박수현 (부경대학교 식품생명공학부) ;
  • 김동우 (부경대학교 식품생명공학부) ;
  • 김정민 (부경대학교 식품생명공학부) ;
  • 이희삼 (농업과학기술원 잠사곤충부) ;
  • 류강선 (농업과학기술원 잠사곤충부)
  • 발행 : 2000.12.01
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초록

This study was designed to investigate the effect of silkworm powder on oxygen radicals and their scavenger enzymes in brain membrances of SD rats. Hydroxyl radical (OH) levels resulted in a considerable decreases in brain mitochondria fraction. Superoxide radical (O$_2$) levels were a slightly decreased in brain cytosol fraction. Lipid peroxide (LPO) and Oxidized protein (OP) levels were significantly decreased in brain mitochondria and microsomes fraction. Mn-superoxide dismutase (SOD) activity was remarkably increased in the mitochondria fraction. Cu and Zn-SOD activities were effectively increased in brain cytosol fraction. GSHPx activity was considerably increased in brain cytosol fraction. These results suggest that anti-aging effect of silkworm plays an effective role in attenuating an oxidative stress and increasing a scravenger enzyme activity in brain membranes.

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