Journal of Sericultural and Entomological Science (한국잠사곤충학회지)

Korean Society of Sericultural Science (한국잠사학회)
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Effect of Silkworm Powder on Oxygen radicals and Their Scavenger Enzymes in Brain membranes of SD Rats

뇌조직의 활성산소 및 그 제거효소에 미치는 누에분말의 영향

  • 최진호 (부경대학교 식품생명공학부) ;
  • 김대익 (부경대학교 식품생명공학부) ;
  • 박수현 (부경대학교 식품생명공학부) ;
  • 김동우 (부경대학교 식품생명공학부) ;
  • 김정민 (부경대학교 식품생명공학부) ;
  • 이희삼 (농업과학기술원 잠사곤충부) ;
  • 류강선 (농업과학기술원 잠사곤충부)
  • Published : 2000.12.01
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Abstract

This study was designed to investigate the effect of silkworm powder on oxygen radicals and their scavenger enzymes in brain membrances of SD rats. Hydroxyl radical (OH) levels resulted in a considerable decreases in brain mitochondria fraction. Superoxide radical (O$_2$) levels were a slightly decreased in brain cytosol fraction. Lipid peroxide (LPO) and Oxidized protein (OP) levels were significantly decreased in brain mitochondria and microsomes fraction. Mn-superoxide dismutase (SOD) activity was remarkably increased in the mitochondria fraction. Cu and Zn-SOD activities were effectively increased in brain cytosol fraction. GSHPx activity was considerably increased in brain cytosol fraction. These results suggest that anti-aging effect of silkworm plays an effective role in attenuating an oxidative stress and increasing a scravenger enzyme activity in brain membranes.

Keywords

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