한국미생물·생명공학회지 (Microbiology and Biotechnology Letters)

  • 제28권5호
  • /
  • Pages.291-297
  • /
  • 2000
  • /
  • 1598-642X(pISSN)
  • /
  • 2234-7305(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Penicillium sp. Y-8515에 의한 Compactin 생산

Production of Compaction from Penicillium sp. Y-8515

  • 박주웅 (영진약품공업(주) 중앙연구소) ;
  • 이주경 (영진약품공업(주) 중앙연구소) ;
  • 권태종 (건국대학교 미생물공학과) ;
  • 박용일 (생명공학연구소(KRIBB)) ;
  • 강상모 (건국대학교 미생물공학과)
  • 발행 : 2000.10.01
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초록

A strain producing high levels of compaction was isolated from soil and identified as Penicillium sp. Y-8515 based on the morphological characteristics and ribosomal RNA sequence analysis. Optimization of several different carbon and nitrogen sources for the effective production of compaction was performed resulting in the medium compositions containing 5%(w/v) glucose, 1.0 % soybean meal, 0.5% yeast extract, 0.5%(NH$_4$)$_2$$SO_4$, 0.25%,$ NaH_2$$PO_4$, 0.25% $CaCO_3$. The fixed con-centration of glucose(5%, w/v) and relatively lower concentrations(less than 2.5%, w/v) of soybean meal stimu-lated the transformation of the growth morphology from filamentous to pellet form. Comparing to that by filamentous form, the production of compactin by pellet form increased up to 1.5 folds. In a fed-batch fermentation, continuous feeding of the mixture of glucose and nitrogen source at the ratio of 10:1 showed 3.5-fold more produc-tion yield of compaction comparing to the batch mode.

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참고문헌

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