Microbiology and Biotechnology Letters (한국미생물·생명공학회지)

The Korean Society for Microbiology and Biotechnology (한국미생물·생명공학회)
권호 표지

Effect and Development of Automatic Control of Dissolved Oxygen on Growth of Phellinus linteus WI-001

Phellinus linteus WI-001 균사체의 성장에 미치는 용존산소농도의 영향 및 자동 조절방법 개발

  • 김종래 (환인제약(주) 중앙연구소,강원대학교 자연과학대학 생명과학부) ;
  • 권호균 (환인제약(주) 중앙연구소) ;
  • 전계택 (강원대학교 자연과학대학 생명과학부) ;
  • 이계관 (환인제약(주) 중앙연구소)
  • Published : 2000.10.01
Download PDF
⟨ Previous Next ⟩

Abstract

The effects of dissolved oxy-gen(DO) concentration and DO control modes on cell growth in a 4L computer-controlled bioreactor system were investigated using Phellinus linteus WI-001, a producer of protein-polysaccharides having potent anticancer activi-ties. When DO was controlled at about 20%, maximum cell concentration and specific growth rate of the strain were observed to increase 36% and 64%, respectively, as compared to the experiment performed without DO control. By adopting cascade automatic control of DO ar 20% in a mixed automatic control mode using computer-con-trolled program, 19.5g/L of maximum cell concentration was obtained. These results showed that the mixed auto-matic control mode was the effective method for enhancing cell growth of the shear sensitive Phellinus linteus.

Keywords

References

  1. Arch. Pharm. Res. v.16 no.4 Effect of Kp, an antitumor protein-polysaccharide from mycelial culture of Phellinus linteus on the humoral immune response of tumor-bearing ICR mice to sheep red blood cells Chung, K. S.;S. S. Kim;H. S. Kim;K. Y. Kim;M. W. Han
  2. Biotechnol. Bioeng. v.55 Biodegradation of phenol at high initial concentration in two-phase partitioning batch and fed-batch bioreactors Collins, L. D.;A. J. Daugulis
  3. Gann. v.59 Antitumor action of some basidiomycetes, especially Phellinus linteus Ikekawa, Y.;M. Nakanishi;N. Uehara;G. Chihara;F. Fukuoka
  4. J. Immunol. Jmmunophamacol. v.11 Immunmodulatory substances of fungal origin Jong, S. C.;J. M. Birmingham;S. H. Pai
  5. J. Microbiol. Biotechnol. v.20 no.3 Anti-tumot and immuno-stimulating activity of fungal polysaccharides Lee, J. H.
  6. J. Microbiol. Biotechnol. v.6 Immunostimulating activity and characterization of polysaccharides from mycelium of Phelliuns linteus Lee ,J. H.;S. M. Cho;K. S. Song;S. B. Han;H. M. Kim;N. D. Hong;I. D. Yoo
  7. Chem. Pharm. Bull. v.36 no.4 Potentiation of host-mediated antitumor activity by orally administered mushroom (Agaricus bisporus) Fruit bodies Nanba, H.;H. Kuroda
  8. Appl. Microbial. v.22 Antibiotic synthesis and morphological differentiation of Cephalosporium acremorium Nash, C. H.;F. M. Huber
  9. Biotechnol. Bioeng. v.8 Dissolved oxygen measurements in polot and production-scale novobiocin fermentation Steel, M. R.;W. D. Maxon
  10. Process Biochem. v.18 Problems of mass and momentum fransfer in large fermentors Vardar, F.