Perspectives on Functional Genomics

  • Song, Kyuyoung (Department of Biochemistry, University of Ulsan College of Medicine)
  • Published : 2000.09.01

Abstract

As the first assembly of the human genome was announced on June 26, 2000, we have entered post genome era. The genome sequence represents a new starting point for science and medicine with possible impact on research across the life sciences. In this review I tried to offer brief summaries of history and progress of the Human Genome Project and two major challenges ahead, functional genomics and DNA sequence variation research.

Keywords

References

  1. Science v.262 A new five-year plan for the U.S. human benima program Collins, F. S;D. Galas
  2. Science v.282 New goals for the U.S. human genome project;1998-2003 Collins, F. S;A. Patrinos;E. Jordon;A. Chakravarti;R. Gesteland;L. Walters;the members of the DOE;NIH planning groups
  3. Science v.270 An STS-based map of the human genome Hudson, T. J.;L. D. Stein;S. S. Gerety;J. Ma;A. B. Castle;J. Silva;D. K. Slonim;R. Baptista;L. Kruglyak;S. H. Xu(et al)
  4. Nature v.380 A comprehensive genetic map of human genome based on 5.246 microstellites Dib, C;S. Faure;C. Fizames;D. Samson;N. Drouot;A. Vignal;P. Millasseau;S. Marc;J. Morissette;J. Weissenbach
  5. Science v.274 A gene map of the human genome Schuler, G. D;M. S. Boguski;E. A. Stewart;L. D. Steinl;G. Gyapay;K. Rice;R. E. White;P. Rodriguez-Tome;A. Aggarwal;E. Bojorek;S. Bentolila;B. B. Birren;A. Butler;A. B. Castle;N. Chiannikulchai;A. Chu;C. Clee;S. Cowles;P. J. Day;T. Dibling;N. Drouot;I. Dunham;S. Duprat;C. East.T. J. Hudson(et al)
  6. Science v.277 The complete genome sequence of Escherichia coli K-12 Blattner, F. R.;plunkett G 3rd;C. A. Bloch;N. T. Perna;V. Berland;M. Riley;J. Collado-Vides;J. D. Glasner;C. K. Rode;G. F. Mayhew;J. Gregor;N. W. Davis;H. A. Kirkpatrick;M. A. Goeden;D. J. Rose;B. Mau;Y. Shao
  7. Nature v.387(suppl) The yeast genome directory
  8. Science v.282 Genome sequence of the nematode Caenohabditis elegans;A platform for investigating biology The Caenorhabditis elegans Sequencing Consortium
  9. Science v.287 The genome sequence of Drosophila melanogaster
  10. Science v.252 Complementry DNA sequencing;expressed sequence tags and human genome project Adams, M. D.;J. D. Gocayne;M. Dubnick;M. H. Polymeropoulos;H. Xiao;C. R. Merril;A. Wu;B. Olde;R. F. Moreno;A. P. Kerlavage;W. R. McCombie;J. C. Venter
  11. Science v.286 The mammalian gene collection Strausberg, R. L.;E. A. Feingold;R. D. Klausner;F. S. Collins
  12. Science v.274 The New Genomics;Global Views of Biology Lander, E. S.
  13. Electrophoresis v.20 Expression profiling in cancer using cDNA microarraus Khan, j.;L. H. Saal;M. L. Bittner;Y. Chen;J. M. Trent;P. S. Meltzer
  14. Nat. Genet. v.21 Array of hope Lander, E. S.
  15. Curr. Opin. Biotechnol v.11 Microarray technology;enhanced versatility, persistent challenge Epstein,C. B.;R. A. Butow
  16. Nat. Genet. v.14 Use of a cDNA microarray to analyse gene expression patterns in human cancer DeRisi, J.;L. Penlan;P. O. Brown;M. L. Bittner;P. S. Meltzer;M. Ray;Y. Chen;Y. A. Su;J. M. Trent
  17. Nat. Biotechnol v.14 Expression monitoring by hybridization to high-density oligonucleotide arrays Lockhart, D. J.;H. dong;M. C. Byrne;M. T. Follettie;M. V. Gallo;M. S. Chee;M. Mittmann;C. Wang;M. Kobayashi;H. Horton;E. L. Brown
  18. Curr. Biol. v.9 Microarray analysis of replicative senescence Shelton, D. N.;E. Chang;P. S. Whittier;D. Choi;W. D. Funk
  19. Science v.286 Microarray analysis of Drosophila development during metamorphosis White, K. P.;S. A. Rifkin;P. Hurban;D. S. Hogness
  20. Virology v.266 Large-scale monitoring of host cell gene expression during HIV-1 infection using cDNA microarrays Geiss, G. K.;R. E. Bumgarner;M. C. An;M. B. Agy;A. B. van’t Wout;E. Hannersmark;V. S. Carter;D. Upchurch;J. I. Mullins;M. G. Katze
  21. Proc. Natl. Acad. Sci. USA 95 Cluster analysis and display of genome-wide expression pattern Eisen, M. B.;P. T. Spellman;P. O. Brown;D. Botstein
  22. Proc. Natl. Acad. Sci. USA 96 Interpreting patterns of gene expression with self-organizing maps;methods and application to hematopoietic differentiation Tomayo, P.;D. Slonim;J. Mesirov;Q. Zhu;S. Kitareewan;E. Dmitrovsky;E. S. Lander;T. R. Golub
  23. Proc. Natl. Acad. Sci. USA 96 Broad patterns of gene expression revealed by clustering analysis of tumor and normal colon tissues probed by oligonucleotide arrays Alon, U.;N. Barkai;D. A. Notterman;K. Gish;S. Ybarra;D. Mack;A. J. Levine
  24. Science v.286 Molecular classification of cancer;class discovery and class prediction by gene expression monitoring Golub, T. R.;D. K. Slonim;P. Tamayo;S. Huard;M. Gaasenbeek;J. P. Mesirov;H. Coller;M. L. Loh;J. R. Downing;M. A. Caligiuri;C. D. Bloomfield;F. S. Lander
  25. Nature v.403 Distinct types of diffuse large B-cell lymphoma identified by gene expression profiling Alizadeh, A.A.;M. B. Eisen;R. E. Davis;C. Ma;I. S. Lossos;A. Rosenwald;J. C.Boldrick;H. Sabet;T. Tran;X. Yu;J. I. Powell;L. Yang;G. E. Marti;T. Moore;J. Hudson;L. Lu;D. B. Lewis;R. Tibshrani;G. Sherlock;W. C. Chan;T. C. Greiner;D. D. Weisenburger;j. O. Armitage;R. Warnke;R. levy;W. Wilson;M. R. Grever;J. C. Byrd;D. Bostein;P. O. Brown;L. M. Staudt
  26. Nat. Genet. v.24 A gene expression database for the molecular pharmacology of cancer Sherf, U.;D. T. Ross;M. Waltham;L. H. Smith;J. K. Lee;L. Tanabe;K. W. Kohn;W. C. Reinhold;T. G. Myers;D. T. Andrews;D. A. Scudiero;M. B. Eisen;E. A. Sausville;Y. pommier;D. Botstein;P. O. Brown;J. N. Weinstein
  27. Nat. Genet. v.24 Systematic variation in gene expression patterns in human cancer cell lines Ross, D. T. ;U. Schertf;M. B. Eisen;C. M. Perou;C. Rees;P. Spellman;V. Iyer;S. S. Jeffrey;M. Van de Rijn;M. Waltham.A. Pergamenschikov;J. C. Lee;D. Lashkari;D. Shalon;T. G. Myers;J. N. Weinstein;D. Botstein;P. O. Brown
  28. Net. Genet. v.1 Positional cloning;let’s not call it reverse anymore Collins, F. S.
  29. Net. Genet. v.9 Positional cloning moves from perditional to traditional Collins, F. S.
  30. Science v.273 The future of genetic studies of complex human diseases Risch. N;K. Merikangas
  31. Net. Genet. v.17 THe use of genetic map of bialleliv markers in linkage studies Kruglyak, L
  32. Science v.278 Variations on a theme;cataloging human DNA sequence variation Collins, F. S.;M. S. Guyer;A. Chakravarti
  33. Gene v.234 The essence of SNPs Brookes, A. J.
  34. Science v.278 Playing chicken over gene markers Marshall, E.
  35. Genome Res v.8 A DNA polymorphism discovery resources for research on human genetic variation Collins, F. S.;L. D. Brools;A. Chakravarti
  36. Net. Genet. v.21 Reliable identification of large numbers of candedate SNPs from public ESTdata Buetow, K. H.;M. N. Edmodson;A, B, Cassidy
  37. Science v.284 Drug firm to create public database of genetic mutations Marshall, E.
  38. Net. Genet. v.23 A general approach to single-nucleotide polymorphism discovery Marth. G. T.;I. Korf;M. D. Yandell;R. T. Yeh;Z. Gu;H. Zakeri;N. O. Stitziel;L. Hillier;P-Y. Kwok;W. R. Gish
  39. Science v.280 Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome Wnag, D. G.;J. -B. Fan;C. -J. Siao;A,. Berno;P. Young;R. Sapolsky;G. Ghandour;N. PErkins;E. Winchester;J. Spencer;L. Kryglyak;L. Stein;L. Hsie;T. Topaloglou;E. Hubbell;E. Robinson;M. Mittmann;M. S. Morris;N. Shen;D. Kilburn;J. Rioux;C. Nusbaum;S. Rozen;T. J. Hudson;R. Lipshutz;M. Chee;E. S. Lander
  40. Net. Genet. v.22 Characterizarionof a single-nucleotkde polymorphisms in coding regions of human genes Cargill, M. D.;Altshuler;J. Ireland;P. Sklar;K. Ardlie;N. Patil;C. R. Lane;E. P. Lim;N. Kalvanaraman;J. Nemesh;L. Ziaugra;L. Friedland;A. Rolfe;J. Warrington;R. Lipshutz;G. Q. Daley;E. S. Lander
  41. Nat. Genet v.22 Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure hpmeostasis Halushka, M. K.;J. -B. Fan;Bentley, L. Hsie;N. Shen;A. Weder;R. Cooper;R. Lipshutz;A. Chakravarti
  42. Science v.28/6 Pharmacogenomics;translating fuctional genomics into rational therapeutics Evans, W. E.;N. V. Relling
  43. Science v.287 Harnessing the power of the genome in the search for new antibiotics Rosamond, j;A. Allosop
  44. Science v.287 Bioinformatics in the information age Spengler, S. J
  45. Nature v.404 Next-generation biologists must straddle computation and biology Wickware, P
  46. Curr. Opin. Biotechnol v.2 Genomic analysis Lee, P. S.;K. H. Lee
  47. Nature v.402 A Post-genomic challenge;Learning to read patterns of protein synthesis Abbott,A
  48. Science v.288 Protein data justice for all Service, R. F.
  49. Curr. Opin. Biotechnol v.2 Protepmic analysis Dutt, M. J;K. H. Lee
  50. Science v.287 Genomic medicine and the future of health care Sander, C
  51. Science v.287 The end of the beginning Brenner, S