Journal of Nutrition and Health

The Korean Nutrition Society (한국영양학회)
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Serum Folate Levels of Maternal-Umbilical Cord Blood and Pregnancy Outcomes

임신말 모체 및 제대 혈청의 엽산 농도와 임심결과

  • 안홍석 (성신영자대학교 식품영양학과) ;
  • 김지선 (성신영자대학교 식품영양학과) ;
  • 이금주 (성신영자대학교 식품영양학과) ;
  • 김영태 (고려대학교 의과대학 산부인과)
  • Published : 2000.12.01
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Abstract

This study was out to evaluate the folate nutritional status of Korean pregnant women and to investigate the relationship between serum folate levels of maternal-umbilical cord blood and pregnancy outcomes. Folate intakes of the pregnants was estimated by dietary folate intakes obtained from semiquantitative frequency questionnaire and supplementary folate intakes. The serum folate levels in both maternal blood and umbilical cord of 29 pregnant women at delivery and 13 nonpregnant controls were measured by redioimmunoassay. The total folate intakes(dietary and supplementary)of the pregnant women was 465. 4$\mu\textrm{g}$/d which was 93% of the Korean RDA for folate. Maternal mean serum folate levels of the pregnants was 6.1$\mu\textrm{g}$/ml, significantly lower than that of nonpregnant women(8.9ng/ml). Mean serumfolate level of umbilical cord blood was 14.2ng/ml, which was 2.3 folds higher than that of maternal blood. This finding indicates that the uptake of folate in the fetus may be due to an active placental transport mechanism. Maternal serum folate level correlated positively with that of umbilical cord blood, showing that folate concentration of umbilical cord blood is affected by maternal status. There was no significant correlation between the serum folate levels in maternal-umbilical cord blood and the pregnancy outcomes.(Korean J Nutrition 33(8) : 840-847, 2000)

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