Preventive Nutrition and Food Science
- 제5권1호
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- Pages.37-41
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- 2000
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- 2287-1098(pISSN)
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- 2287-8602(eISSN)
Effects of Ethylacetate Fraction of Persimmon Leaves on Experimentally-induced Gastric Mucosal Damage and Gastric Ulcers in Rats
- Choo, Myung-Hee (Chosun University) ;
- Park, Hyun-Suk (Chosun University) ;
- Shin, Kil-Man (Chosun University) ;
- Jung, Soon-Teck (Mokpo National University) ;
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Kim, Kyong-Su
(Chosun University) ;
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Lee, Myung-Yul
(Chosun University)
- 발행 : 2000.03.01
초록
The protective effects of the ethylacetate fraction of persimmon leaves(PEF) against experimentally induced gastric mucosal damage and gastric ulcers were evaluated in ratss. In prophylatic study, 100 mg/kg ethylacetate fraction of persimmon leaves (PEFH) exhibited a total protection of 73.8% and 65.7% against HCl-ethanol and 0.2N NaOH-induced gastric mucosal membrane lesions, respectively, which was superior to cimetidine 50 mg/kg, a commonly used anti-ulcer drug. PEFH showed excellent anti-ulcer effects against pylorus ligation induced gastric ulcers, compared to the control group, however, 50 mg/kg ethylacetate fraction of persimmon leaves (PEFL) and PEFH did not affect ulcers induced by water immersion stress, and that is inferior to cimetidine 50 mg/kg. In conclusion, the results suggest that the ethylacetate fraction of persimmon leaves can be used both in prevention and treatment of experimentally induced gastric mucosal damage and ulcers.
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