Textile Science and Engineering (한국섬유공학회지)

The Korean Fiber Society (한국섬유공학회)
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Application of Drug Release Carrier with Block Copoly(esterether) Comprising Poly(L-lactide) and Poly(oxyethylene)

Poly(L-lactide)(PLLA)/Polyoxyethylene(POE) 블록공중합체의 약불방출담체에 관한응용

  • Lee, Chan-Woo (Department of Innovativa Industrial & Technology, Hoseo University) ;
  • Ihm, Dae-Woo (Department of Innovativa Industrial & Technology, Hoseo University) ;
  • Jun, Kun (Korea Research Institute of Chemical Technology)
  • 이찬우 (호서대학교 공과대학 첨단산업기술) ;
  • 임대우 (호서대학교 공과대학 첨단산업기술) ;
  • 전근 (한국화학연구소 염료염색가공센터)
  • Published : 2000.07.01

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Abstract

An A-B-A block copoly(ester-ether) comprising poly(L-lactic acid)(PLLA, A) and poly (oxyethylene)(POE, B) was prepared by copolymerization. The release rate of the model drugs form PLLA/POE particles was studied by varying the hydrophilicity of the model drugs as well as that of the copolymers. It was observed that the rate of controlled release from the copolymer microspheres is not dependent on the degradation of the polymer, but on the wall permeability which is defined as the product of diffusion coefficient and the solubility coefficient. The release rate was fast as long as the hydrophilicity of the copolymer was high, regardless of the composition of the copolymer. It was also found that the release rate was faster as the monomer composition of the oxyethylene unit becomes higher.

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