Characterization of the $\alpha$-mannosidase Gene Family in Filamentous Fungi: N-glycan Remodelling for the Development of Eukaryotic Expression Systems

  • Eades, C.Joshua (Department of Biology, University of Victoria) ;
  • Hintz, William E. (Department of Biology, University of Victoria)
  • Published : 2000.07.01

Abstract

Although filamentous fungi are used extensively for protein expression, their use for the production of heterologous glycoproteins is constrained by the types of N-glycan structures produced by filamentous fungi as compared to those naturally found on the glycoproteins. Attempts are underway to engineer the N-glycan synthetic pathways in filamentous fungi in order to produce fungal expression strains which can produce heterologous glycoproteins carrying specific N-glycan structures. To fully realize this goal, a detailed understanding of the genetic components of this pathway in filamentous fungi is required. In this review, we discuss the characterization of the $\alpha$-mannosidase gene family in filamentous fungi and its implications for the elucidation of the N-glycan synthetic pathway.

Keywords

References

  1. Glyco-aonj. J. v.16 Filamentous fungi as production or-ganisms for glycoproteins of bio-medical interest Maras, M.;I. van Die;R. Contreras;C. A. M. J. J. van den Hondel
  2. Crit. Rev. Biotechnol v.17 The molecular biol-ogy of secreted enzyme production by fungi Archer, D. B.;J. F. Peberdy
  3. Can. J. Bot. v.73 no.Sup. 1E-H Improved gene expression i Aspergillus nidulans Hintz, W. E.;I. Kalsner;E. Plawinski;S. M. Guo;P. A. Lagosky
  4. Biotechnol. v.23 Expression of foreign proteins in the genus Aspergillus Gwynne, D. I.;M. Devchand
  5. Glycobiol. v.3 Biological roles of oligosaccharides: all of the theories are correct Varki, A.
  6. Bio-technol v.9 The oligosaccharides of gly-coproteins: bioprocess factors affecting the oligosaccaride structure and their effect on glycoprotein properties Goochee, C. E.;M. J. Gramer;D. C. Anderson;J. B. Bahr;J. R. Rasmussen
  7. Ann. Rev. Biochem. v.54 Assembly of asparagine-linked oligosaccarides Kornfeld, R.;S. Kornfeld
  8. Biochim. Biophys. Acta v.1426 Processing glycosidases of Saccha-romyces cerevusiae Herscovics, A.
  9. Biochem. Soc. Trans. v.26 Enzymology of cell-wall degradation Henrissat, B.
  10. Bio-chem. J. v.280 A classification system of glycosyl hydrolases based on amino acid sequence similarity Henrissat, B.
  11. Biochim. Biophys. Acta v.1426 Asparagine-linked glycosylation in the yeast Golgi Dean, N.
  12. FASEB v.7 Glycoprotein biosyn-thesis in yeast Herscovics, A.;P. Orlean
  13. Eur. J. Biochem. v.249 In vitro conversion of the carbohydrate moiety of fungal glycoproteins to mam-malian-type oligosaccharides - evidence for N-acetyl-glucosaminyltransferase-I-accepting glycans from Tricho-derma reesei Maras, M.;X. Saelens;W. Laroy;K. Piens;M. Claeyssens;W. Fiers;R. Contreras
  14. Curr. Microbol. v.27 The carbohydrate moiety of the acid carboxypeptidase from Aspergillus satoi Chiba, Y.;Y. Yamagata;S. Iijima;T. Nakajima;E. Ichishima
  15. Evolution by Gene Duplication no.Springer-Verlag Ohno, S.
  16. Molecular Evolution Li, W. H.
  17. Ann. Rev. Biochem. v.64 The multiplicity of domains in proteins Doolittle, R. F.
  18. Genetics v.139 How often do duplicated genes evolve new functions Walsh, J. B.
  19. Proc. Natl. Acad. Sci. USA v.91 Invasion and maintenance of a gene duplication Clark, A. G.
  20. Genetics v.138 Further examples of evolution by gene duplication revealed through DNA sequence comparisons Ohta, T.
  21. Theor. Pop. Biol. v.37 How gene families evolve Ohta, T.
  22. Genome v.138 Role of gene duplication in evolution Ohta, T.
  23. Proc. R. Soc. London B v.256 The evolution of funtionally novel proteins after gene duplication Hughes, A. L.
  24. Mol. Biol. Evol. v.15 The fre-quency distribution of gene family sizes in complete ge-nomes Huynen, M. A.;E, van Nimwegen
  25. Proc. Natl. Acad. Sci. USA v.91 Evolution of gene networks by gene duplications: a mathematical model and its implications on genome organization Wagner, A.
  26. Nature v.387 Molecular evidence for an ancient duplication of the entire yeast genome Wolfe, K. H.;D. C. Shields
  27. Mol. Biol. Evol. v.10 Evolution of du-plicate genes in a tetrapliod animal, Xenopus laevis Hughes, M. K.;A. L. Hughes
  28. BioEssays v.14 Redundancies, development and the flow of infomation Tautz, D.
  29. Gene Characterization of the Class I α-mannosidase gene family in the filamentous fungus Aspergillus nidulans Eades, C. J.;W. E. Hintz
  30. Glycobiol v.4 Glycosidases of the asparagine-linked oligosaccharide processing pathway Moremen, K. W.;R. B. Trimble;A. Herscovics
  31. Genetics v.147 Comparable rates of gene loss and functional divergence after genome dupli-cations early in vertebrate evolution Nadeau, J. H.;D. Sankoff
  32. Fungal Gen. Biol. v.21 Metabolic pathway clusters in filamentous fungi Nadeau, J. H.;D. Sankoff
  33. Glycobiol. v.4 Mammalian α-mannosidases-multiple forms but a com-mon purpose Daniel, P. F.;B. Winchester;C. D. Warren
  34. Glycobiol. v.8 Identification and analysis of a Class 2 α-mannosidase from Aspergillus nidulans Eades, C. J.;A. M. Gilbert;C. D. Goodman;W. E. Hintz
  35. Biochim. Biophys. Acta v.1253 Molecular cloning and nucleotide sequence of the 1,2-α-D-mannosidase gene, msdS, from Aspergillus satoi and ex-pression of the gene in yeast cells Inoue, T.;T. Yoshida;E. Ichishma
  36. Biochim. Biophys. Acta v.1263 Molecular cloning and nucleotide sequence of the genomic DNA for 1,2-alpha-D-mannosidase gene, msdC from Penicillium citri-num Yoshida, T.;E. Ichishma
  37. J. Bacteriol. v.77 Molecular cloning and en-zymatic characterization of a Trichoderma reesei 1,2,-α- D-mannosidase Maras, M. N.;Callewaert;K. Piens;M. Claeyssens;W. Martinet;S. Dewaele;H. Contrerad;I. Dewerte;M. Pent-tila;R. Contreras
  38. Eur. J. Biochem. v.253 Mutant analysis reveals an alternative path-way for N-linked glycosylation in Drosophila melano-gaster Roberts, D. B.;W. J. Mulvany;R. A. Dwek;P. M. Rudd
  39. Glycoconj. J. v.12 Insertion into Aspergillus nidulans of functional UDP-GlcNAc: α3-D-mannoside β-1,2-N-acetylglucosaminyl-transferase I, the enzyme catalyzing the first committed step from oligomannose to hybrid and complex type N-Glycans Kalsner, I.;W. Hintz;L. S. Reid;H. Schachter
  40. Microbiology v.143 Cell wall protein mannosylation determines Candida albicans cell surface hydrophobicity Masuoka, J.;K. C. Hazen
  41. J. Biol. Chem. v.268 High affinity binding of a glycopeptide elicitor to tomoto cells and mi-crosomal membranes and displacement by specific glycan suppressors Basse, C. W.;A. Fath;T. Boller
  42. J. Biol. Chem. v.267 Elicitors and suppressors of the defense response in tomato cells -puri- fication and characterization of glycopeptide elicitors and glycan suppressors generated by enzymatic cleavage of yeast invertase Basse, C.;W. K. Bock;T. Boller
  43. Mycol. Res. v.101 Surface glycoproteins associated with appressorium formation and adhesion in Phytophthora palmivora Bircher, U.;H. R. Hohl
  44. Botanica Helvetica v.105 The influence of IgG, proteases, and glycosidases in ashesion to and infection of soybean plants by Phytophthora me-gasperma f. sp. glycinea Hollenstein, L.;S. Balsiger;H. R. Hohl
  45. Phytopathology v.86 Endopolygactu-ronase from Fusarium oxysporum f. sp. lycopersici: puri-fication, characterization, and production during infec-tion of tomato plants Di Pietro, A.;M. I. G. Roncero
  46. Plant Physiol. v.95 Ethylene biosyn-thesis-inducing xylanase. Purification and physical char-acterization of the enzyme produced by Trichoderma viride Dean, J. F. D.;J. D. Anderson
  47. Naturwissenschaften v.68 Fungal elictors of the phytoalexin re-sponse in higher plants West, C. A.
  48. Appl. Biosci. v.10 On global sequance alignments Huang, X.
  49. PAUP* Phylogenetic analysis us-ing parsimony (* and other methods) Swofford, D. L.
  50. Eur. J. Biochem. v.217 Molecular cloning and primary structure of Man-mannosidase from human kidney Bause, E.;E. Bieberich;A. Rolfs;C. Volker;B. Schmidt
  51. Glycobiol. v.8 Molecular cloning, chromosomal mapping and tis-suespecific expression of a novel human α-1,2-manno-sidage gene involved in N-glycan maturation Tremblay, L. O.;N. Campbell Dyke;A. Herscovics
  52. J. Biol. Chem. v.269 Isolation adn expression of murine and rabbit cDNAs encoding an α-1,2-mannosidase involved in the processing of asparagine-linked oligosaccharides Lal, A.;J. S. Schutzbach;W. T. Forsee;P. Neame;K. W. Moremen
  53. J. Biol. Chem. v.269 Isolation of a mouse Golgi mannosidase cDNA, member of a gene family conserved from yeast to mammals Herscovics, A.;J. Schneikert;A. Athanassiadis;K. W. Moremen
  54. Eur. J. Biochem. v.246 Man-mannosidase from pig liver is a type-II membrane protein that resides in the endoplas-mic reticulum -cDNA cloning and expression of the en-zymes in COS 1 cells Bieberich, E.;K. Treml;C. Volker;A. Rolfs;B. Kalz-Fuller;E. Bause
  55. Dev. Biol. v.168 Molecular and genetic analysis of the Drosophila mas-1 (mannosidas-1) gene which en-codes a glycoprotein processing α-1,2-manosidase Kerscher, S.;S. Albert;D. Wucherpfending;M. Heisenberg;S. Schneuwly
  56. Glycobiol. v.7 Isola-tion and characterization of an α-1,2-mannosidase cDNA from the lepidopteran insect cell line Sf9 Kawer, Z.;A. Herscovics;D. L. Jarvis
  57. J. Biol. Chem. v.266 Glycoprotein biosynthesis in Saccharomyces cere-visiae: isolation and characterization of the gene encod-ing a specific processing α-mannosidase Camirand, A.;A. Heysen;B. Grondin;A. Herscovics