Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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Anti-diabetic effect of Yukmijihwangtang-Jahage in obese Zucker rats

초록 : 비만 실험동물쥐 (obese Zucker rats)에서의 육미지황탕의 항당뇨 효과

  • Kim, Cheorl-Ho (Department of Gynecology, Biochemistry and Molecular Biology, College of Oriental Medicine) ;
  • Seo, Eun-Kyung (Department of Gynecology, Biochemistry and Molecular Biology, College of Oriental Medicine) ;
  • Kang, Dong-Hwi (Department of Gynecology, Biochemistry and Molecular Biology, College of Oriental Medicine) ;
  • Seo, Jin-Woo (Department of Gynecology, Biochemistry and Molecular Biology, College of Oriental Medicine) ;
  • Kim, Kyoung-Sook (Faculty of Natural Resoruces and Life Science, Dong-A University) ;
  • Lee, Tae-Kyun (Department of Gynecology, Biochemistry and Molecular Biology, College of Oriental Medicine) ;
  • Lee, Young-Choon (Faculty of Natural Resources and Life Science, Dong-A University) ;
  • Nam, Kyung-Soo (Department of Phamacology, College of Medinicine, Dongguk University, Kyung-Pook)
  • Published : 2000.08.01
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Abstract

The effect of the traditional herbal medicine Yukmijihwangtang-Jahage(YJ) on the improvement of insulin resistance and lipid profile was studied using a model for non-insulin dependent diabetes mellitus, lean (Fa/-) and obese (fa/fa) Zucker rats. Yukmijihwangtang-Jahage feeding for 4 weeks resulted in a significant decrease in the concentration of plasma triglyceride in both lean and obese Zucker rats. Furthermore, Yukmijihwangtang-Jahage markedly decreased both plasma cholesterol and fasting plasma insulin, and significantly decreased the postprandial glucose level at 30 min during oral glucose tolerance test in obese Zucker rats. Although there was no statistical significance, the crude glucose transporter 4 protein level of Yukmijihwangtang-Jahage dieted obese rats tended to increase when compared to that of obese control rats. Therefore, the present results suggested that Yukmijihwangtang-Jahage may be useful in prevention and improvement of metabolic disorders characterized by hyperinsulinemia states such as non-insulin dependent diabetes mellitus, syndrome X and coronary artery disease.

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References

  1. Chem. Pharm, Bull. v.20 Chemical studies on the orietal plant drugs. XXX: sapogenins of the roots of platycodon granem A. DE CANDOLLE(1): Isolation of the sapogenins and the stereochemistry of polygalacic acid. Akiyama, T.;O. Tanaka;S. Shibata
  2. Diabetic Medicine v.15 Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetesmellitus. Provisional report of a WHO Consultation. Alberti, K. G. M. M.;P. Z. Zimmet
  3. J, Nutr. v.117 Effect of distary carbohydrates on glucagon and insulin receptors in genetically obese female Zucker rats. Bhathena, S. J.:P. Aparicio;K. Revett;N. Voyles;L. Recant
  4. Metabolism v.40 The effect of CP 68, 722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats. Bowen, L.;P. P. Stein;R. Stevenson;G. I. Shulman
  5. Fed. Proc. v.36 The Zucker-fatty rat: a review. Bray, G. A.
  6. Diabetes v.37 The triumvirate: β-cell, muscle, liver, a collusion reponsible for NIDDM. DeFronzo, R. A.
  7. Biochem. J. v.186 Insulin resistance in soleus muscle from obese Zucker rats. Involvement of several defective sites. Crettaz, M.;M. Prentki;M. Zaninettie;B. Jeanrenaud
  8. J. Biol. Chem. v.265 Exercise induced recruitment of the insulin-responsive glucose transporter. Evidence for distinct intracellular insulin- and exercise-recruitable transporter pools in skeletal muscle. Douen, A. G.;T. Ramlal;S. A. Rastogi;P. J. Bilan;G. D. Cartee;M. Vranic;J. O. Holloszy;A. Klip
  9. Diabetes v.41 Exercise training increases glucose transporter content in skeletal muscles more efficiently from aged obese rats than young lean rats. Ezaki, O.;M. Higuchi;H. Nakatsuka;K. Kawanaka;H. Itakura
  10. N. Engl. J. Med. v.317 Insulin resistance in essential hypertention . Ferranini, E.;G. Buzzigoli;R. Binadona
  11. J. Nephrol. v.1 The association of hypertention, diabetes,and obesity: A review. Ferranini, E.;R. A. Defronzo
  12. FEBS Lett. v.268 Exercise training increases glucose transporter protein GLUT-4 in skeletal muscle of obese Zucker (fa/fa)rats. Friedaman, J. E.;W. M. Sherman;M. J. Reed;C. W. Elton;G. L. Dohm
  13. Diabetes v.37 Characterization of new oral antidiabetic agent CS-045: Studies in KK and ob/ob mice and Zucker fatty rats. Fujiwara, T.;S. Yoshioka;T. Yoshioka;I. Ushiyama;H. Horikoshi
  14. J. Chem. Soc. Perkin Trans. v.1 Saponins from roots of Platycodon grandiflorum. Part 2: Isolation and structure of new triterpene glycosides. Ishii, H.;K. Tori;T. Tozyo;Y. Yoshimura
  15. Sports Med. v.24 Role of exercise training in the prevention and treatment of insulin resistance and non-insulindependent diabetes mellitus. Ivy, J. L.
  16. Am. J. Physiol. v.251 Glucose transport locus of muscle insulin resistance in obese Zucker rats. Ivy, J. L.;W. M. Sherman;C. L. Cutler;A. L. Katz
  17. J. Clin. Invest. v.87 Decreased in vivo glucose transport but nomal expression of GLUT1 and GLUT4 in skeletal muscle of diabetic rats. Kahn, B.B.;L. Rossetti;H. F. Lodish;M. J. Charron
  18. J. Nutr. Vitaminol. v.41 Effects of Platycodon grandiflorum feeding on serum and liver lipid concentration in rats with diet-induced hyperlipidemia. Kim, K.-S.;O. Ezaki;S. Ikemoto;H. Itakura
  19. J. Nutr. Biochem. Effects of dietary Platycodon grandiflorum on the improvement of insulin resistance in obese Zucker rats. Kim, K.-S.;E.-K. Seo;Y.-C. Lee;Y.-W. Cho;O. Ezaki;T.-K. Lee;C.-H. Kim
  20. J. Clin. Invest. v.85 Glucose transporter levels in spontaneously obese(db/db) insulin-resistant mice. Koranyi, L.;D. James;M. Mueckler;M. A. Permutt
  21. Shoyakugaku zasshi v.40 Immune pharmacological studies on platycodi radix I: Effect on the phagocytosis in mouse. Kubo, M.;T. Nagao;H. Matsuda;K. Namba
  22. Am. J. Physiol. v.267 Comparative effects of IGF-I and insulin on the glucose transporter system in rat muscle. Lund, S.;A. Flyvbjerg;G. D. Holman;F. S. Larsen;O. Pedersen;A. Schmitz
  23. J. Clin. Invest. v.75 Hyperinsulinemia: a link between hypertension obesity and glucose intolerance. Moden, M.;H. Halkin;S. Almog;A. Lusky;A. Eshkol;M. Shefi;A. Shitrit;Z. Fuchs
  24. Arteriosclerosis v.8 Hyperinsulinemia is characterized by jointly disturbed plasma VLDL, LDL and HDL level. A population-based study. Modan,M.;H. Halkin;A. Lusky
  25. J. Biol. Chem. v.236 Regulation of glucose uptake in muscle: 2. ratelimiting steps and effects. Morgan, H. E.;E. Candenas;D. M. Regen;C. R. Park
  26. Shoyakugaku zasshi v.40 Immune pharmacological studies on platycodi radix II: Antitumor activity of inulin from platycodi radix. Nagao, T.;H. Matsuda;K. Namba;M. Kubo
  27. Am. J. Physiol. v.243 Insulin action and resistance in obesity and non-insulin-dependent type II diabetes mellitus. Olefsky, J. M.;O. G. Kolterman;J. A. Scarlett
  28. J. Clin. Invest. v.90 Insulin resistance in obese Zucker rat(fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation. Patricia, A. K.;D. H. Elizabeth;F. H. Michael;S. H. Edward
  29. Diabetes v.39 Evidence againdt altered expression of GLUT1 or GLUT4 in skeletal muscle of patients with obesity or NIDDM. Pedersen, O.;J. F. Bak;P. H. Andersen
  30. Diabetes v.37 Role of insulin resistance in human disease. Reaven, G. M.
  31. Annu. Rev. Med. v.44 Role of insulin resistance in human disease (syndrome X): an expanded definition. Reaven, G. M.
  32. Metabolism v.41 The role of insulin resistance and hyperinsulinemia incoronary heart disease. Reaven, G. M.
  33. Diabetologia v.38 Insulin resistance in skeletal muscle of the male Otsuka Long-Evans Tokushima Fatty rat, a new model of NIDDM. Sato, T.;Y. Asahi;K. Toide;N. Nakayama
  34. J. Chin. Endocronol. Metb. v.66 Resistance to insulin stimulated glucose uptake in patients with hypertention. Shen, D. C.;S. M. Sheih;M. Fuh;Y.-Di. Che;G. M. Reaven
  35. Am. J. Physiol. v.255 Exercise diet reduce muscle insulin resistance in obese Zucker rat. Sherman,W. M.;A. L. Katz;C. L. Cutler;R. T. Withers;J. L. Ivy
  36. Am. J. Hypertens. v.4 Mechanisms of hypertension in diabetes. Sowers, J. R.;S. Khoury;P. Standley;P. Zemel;M. Zemel
  37. Am. J. Hypertens. v.2 Insulin resistance, glucose resistance and hyperinsulinemia in pathients with hypertention. Swislocki, A. L. M.;B. B. Hoffman;G. M. Reaven
  38. Chem. Pharm. Bull. v.23 Studies on the saponins of the root of platycodon grandiflorum. A. DE CANDOLLE I: isolstion and the structure of Platycodin-D. Tada, A.;Y. Kaneiwa;J. Shoji;S. Shibata
  39. Biochem. Pharmacol. v.56 Prevention of dexamethasone-induced insulin resistance by metformin. Thomas, C. R.;S. L. Turner;W. H. Jefferson;C. J. Bailey
  40. Biochem. J. v.299 Insulin stimulation of glucose tranport activity in rat skeletal muscle: increase in cell surface GLUT4 as assessed by photolabelling. Wilson, C.;S. W. Cushman
  41. Diabetes Res. Clin. Pract. v.43 Acute and chronic oral administration of bis(maltolato) oxovanadium(IV) in Zucker diabetic fatty (ZDF) rats. Yuen, V. G.;E. Vera;M. L. Battell;W. M. Li;J. H. McNeill