생명과학회지 (Journal of Life Science)

  • 제10권1호
  • /
  • Pages.79-85
  • /
  • 2000
  • /
  • 1225-9918(pISSN)
  • /
  • 2287-3406(eISSN)
한국생명과학회 (Korean Society of Life Science)
권호 표지

당근 추출 성분의 Quinone reductase 유도활성 효과

The Effects on Quinone ReductaseInduction of Daucus carota L.

  • 한은주 (신라대학교 자연과학대학 식품영양학과) ;
  • 노승배 (양산 대학 식품가공과) ;
  • 배송자 (신라대학교 자연과학대학 식품영양학과)
  • 발행 : 2000.02.01
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Chemoprevention is one of the major strategies for cancer control. It is well established that dietary factors play an important role in modulating the development of certain types of human cancer. The experiment was conducted to determine quinone reductase(QR) activity induction of Daucus carota L. on HepG2 cells. Among various partition layers of roots of Daucus carota L., the ethyl acetate partition layer(DCMEA) and the n-hexane partition layer(DCMH) tested to be most effective which resulted 2.1 and 1.6 respectively compared to the control value of 1.0. In the case of seeds of Daucus carota L. n-butanol partition layer (DCMB) on HepG2 cells at a dose of 200 $\mu\textrm{g}$/$m\ell$ showed the highest induction activity of QR which was 3.0. These results suggest that potentially useful cancer chemoprevention chemicals could be isolated from DCMEA and DCMH of the roots and DCMB of the seeds of Daucus carota L.

키워드

참고문헌

  1. Cancer facts and Figures American cancer society
  2. J. Kor. Soc. Food Sci. Nutr. v.27 Effects of Godulbaegi Extracts on the Stability and Fluidity of Phospholipid liposomal Membranes Bae, S. J.;S. B. Roh;B. M. Jung
  3. Proc. Natl. Acad. Sci. USA v.77 Increase of NAD(P)H: quinone reductase by dietary antioxidants. Possible role in protection against carcinogenesis and toxicity Benson, A.;M. J. Hunkeler;P. Talalay
  4. Cancer Res. v.49 Phase I clinical trial Toxicity and immunologic effects Budd, G. T.;B. Osgood;B. Barna;J. M. Boyett;J. Finke;S. V. Mdendrop;S. Murth;R. M. Bukoski
  5. Mutat. Res. v.101 Screening of antioxidants and other compounds for antimutagenic properties towards benzo(a)pyrene-induced mutagenicity in strain TA98 of Salmonella typhimurium Calls, L. M.;P. D. Sullivan
  6. Elements of human cancer(8th ed.) Cooper, G. M.
  7. Clinical trials in cancer prevention Cancer(Phila) v.60 DeWys, W. D.;W. F. Malone, R. Butrum;M. A. Setili
  8. Proc. Natl. Acad. Sci. USA v.82 Induction of NAD(P)H: quinone reductase in murine hepatoma cells by phenolic antioxidants, azo dyes and other chemoprotectors. A model system for the study of anticarcinogens De Long, M. J.;H. J. Prochaska;P. Talalay
  9. J. Natl. Cancer Inst. v.66 The causes of cancer Quantitative estimate of avoidable risks of cancer in the united states today Doll, R.;R. Peto
  10. Cancer Res. v.41 Drug-mediated increase of tumor immunogenicity in vivo for a new approach to experimental cancer immunothrapy Giampietri, A.
  11. Fundamental of cancer chemother v.102 Hellman, K.;D. Phil;S. K. Carter
  12. J. Kor. Soc. Food Sci. Nutr. v.27 Antimutagenicity and cytotoxicity of Artemisia iwayomogi Kitamura extracts Ham, S. S.;C. K. Chung;J. H. Lee;K. P. Choi;S. W. Jung;E. J. Kim
  13. Yakhak Hoeji v.41 Studies on the Cytotoxic Consitituent of Saururus chinensis$(L_{OUR})B_{AILL}$ Hyun, J. K.
  14. J. Kor. Soc. Food Sci. Nutr. v.25 The antimutagenic and anticancer effect of Taxus cuspidata extracts Hwang, B. H.;J. L. Zhao;K. P. Jung;E. J. Kim;S. S. Ham
  15. Yakhak Hoeji v.42 Antitumor and Immumodulatory Activities of the P. qrandiflorum Cultivated for More Than 20 Years Kim, Y. S.
  16. Arch. Biochem. Biophys. v.190 Metabolism of benzo-(a)pyrene-3,6-quinone and 3-hydroxy benzo (a) pyrene in liver microsomes from 3-methycholanthrene-treated rats. A possible role of DT-diaphorase in the formation of glucuronyl conjugates Lind, C.;H.Vady;L. Ernster
  17. Biosci. Biotech. Biochem. v.60 Anti-tumor promotion with food phytochemicals: A stategy for cancer chemoprevention Murakami, A.;H. Ohigashi;K. Koshimizu
  18. Induction of quinone reductase and its regulatory mechanism at the transcriptional level by Scutellaria baicalensis Park, H. J.
  19. Proc. Natl. Acad. Sci. USA v.90 Chemical and molecular regulation of enzymes that detoxify carcinogens Prestera, T.;W. D. Holtzclaw; Y. Zhangg;P. Talalay
  20. Adv. Anz. Regul. v.33 The electrophile counterattack response: Proteetion against neoplasia and toxicity Prestera, T.;S. R. Spencer;C. Wilczak;Y. Zhangg;P. Talalay
  21. Anal. Biochem. v.169 Direct measurement of NAD(P)H: Quinone reductase from cells cultured in microtitier wells: A Screening assay of anticarcinogenic enzyme in ducers Prochaska, H. J.;A. B. Santamaria
  22. Proc. Natl. Acad. Sci. USA v.85 Identification of a common chemical signal regulation the induction of enzymes that protect against chemical carcinogenesis Talalay, P.;M. J. De Long;H. J. Prochask
  23. Adv. Enz. Regul. v.28 Mechanisms of induction of enzymes that protect against chemical carcinogenesis Talalay, P.
  24. Cancer Res. v.51 Cancer prevention. Recent progress and future opportunities Weinstein, I. B.
  25. FEBS Lett. v.169 Protection against reactive oxygen species by NAD(P)H: quinone reductase induced by the dietary antioxidant buty lated hydroxy anisole(BHA). Decreased hepatic low-level chemiluminescence during quinone reductase redox cycling Wefers, H.;T. Komai;P. Talalay;H. Sies
  26. Cancer Res. v.52 no.Suppl Food-derived mutagens and carcinogens Wakabayashi, K.;M. Nagao;H. Esumi;T. Sugimura
  27. Yakhak Hoeji v.40 Chemical components of Acanthopanax divarcatus and anticancer effect in leaves Yook, C. S.;Y. S. Roh;S. H. Seo;J. Y. Leem;D. R. Han
  28. Proc. Natl. Acad. Sci. USA v.89 A major inducer of anti-carcinogenic protective enzymes from broccol: Isolation and elucidation of structure Zhang, Y.; P. Talalay;C. G. Cho;G. H. Posner
  29. J. Nutr. v.119 Review of epidemiologic that cartenoids reduce the risk of cancer Ziegler, R. G.